Table 3 Mean live flea counts and efficacy relative to placebo at 24 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or spinosad/milbemycin oxime on Day 0

Placebo

Range

69–100

11–96

73–89

60–100

69–94

15–100

A. mean

83.1

75.5

80.5

85.8

84.0

78.5

G. mean¹

82.7^a

65.8^a

80.3^a

84.7^a

83.7^a

70.1^a

Sarolaner

Range

0–0

0–0

0–0

0–0

0–0

0–0

A. mean

0.0

0.0

0.0

0.0

0.0

0.0

Efficacy (%)

100

100

100

100

100

100

G. mean¹

0.0^b

0.0^b

0.0^b

0.0^b

0.0^b

0.0^b

Efficacy (%)

100

100

100

100

100

100

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Spinosad/milbemycin oxime

Range

0–0

0–0

0–0

0–6

0–54

0–68

A. mean

0.0

0.0

0.0

0.8

6.8

19.6

Efficacy (%)

100

100

100

99.1

92.0

75.0

G. mean¹

0.0^b

0.0^b

0.0^b

0.3^b

0.7^b

4.3^c

Efficacy (%)

100

100

100

99.7

99.2

93.9

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

P-value vs. sarolaner

1.000

1.000

1.000

0.5758

0.2499

0.0002