Treatment | Day of infestation | ||||||||
---|---|---|---|---|---|---|---|---|---|
0 | 14 | 28 | 44 | 58 | 74 | 90 | 95 | ||
Placebo | Range | 14 to 36 | 21 to 39 | 21 to 39 | 21 to 37 | 14 to 29 | 18 to 36 | 22 to 31 | 25 to 37 |
AM | 23.5 | 26.3 | 28.8 | 28.0 | 25.0 | 29.0 | 25.8 | 30.5 | |
GMd | 22.8a | 25.8a | 28.2a | 27.6a | 24.4a | 28.3a | 25.6a | 30.2a | |
Sarolaner | Range | 0 to 0 | 0 to 1 | 0 to 1 | 0 to 2 | 0 to 1 | 1 to 11 | 0 to 2 | 0 to 11 |
AM | 0.0 | 0.3 | 0.1 | 0.3 | 0.3 | 5.3 | 0.4 | 3.8 | |
AM Efficacy (%) | 100 | 99.0 | 99.6 | 99.1 | 99.0 | 81.9 | 98.5 | 87.7 | |
GMd | 0.0b | 0.2b | 0.1b | 0.1c | 0.2c | 4.6c | 0.3c | 2.5c | |
GM Efficacy (%) | 100 | 99.3 | 99.7 | 99.5 | 99.2 | 83.8 | 99.0 | 91.9 | |
P-value vs. placebo | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | |
Fluralaner | Range | 0 to 0 | 0 to 3 | 0 to 1 | 0 to 5 | 0 to 8 | 4 to 27 | 4 to 20 | 2 to 32 |
AM | 0.0 | 1.1 | 0.1 | 1.3 | 3.1 | 16.8 | 10.8 | 14.8 | |
AM Efficacy (%) | 100 | 95.7 | 99.6 | 95.5 | 87.5 | 42.2 | 58.3 | 51.6 | |
GMd | 0.0b | 0.8b | 0.1b | 0.9b | 1.6b | 14.8b | 9.1b | 10.8b | |
GM Efficacy (%) | 100 | 96.8 | 99.7 | 96.9 | 93.5 | 47.9 | 64.6 | 64.3 | |
P-value vs. placebo | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.0011 | <0.0001 | <0.0001 | |
P-value vs. sarolaner | 1.0000 | 0.0678 | 1.0000 | 0.0415 | 0.0012 | <0.0001 | <0.0001 | <0.0001 |