Comparative pharmacokinetics of fluralaner in dogs and cats following single topical or intravenous administration

Table 1 Mean (arithmetic) plasma pharmacokinetic parameters for fluralaner in dogs following single topical and i.v. administration

Parameters	Topical	Topical	Topical	Intravenous^b
	12.5 mg/kg	25.0 mg/kg	50.0 mg/kg	12.5 mg/kg
	n = 6	n = 6	n = 6	n = 6
C_max (ng/mL)	358 ± 94	727 ± 191	1698 ± 318	7109 ± 908
t_max ^a (day)	42 (range 21–63)	25 (range 14–56)	25 (range 7–42)	n/a
AUC_(0→t) (day*ng/ml)	18933 ± 3599	41243 ± 7467	85852 ± 17283	87198 ± 11835
AUC_(0→∞) (day*ng/ml)	19577 ± 3982	43375^c ± 8752	93468^c ± 20424	87779 ± 12004
t_1/2 (day)	17 ± 4	21^c ± 3	17^c ± 3	15 ± 2
t_last (day)	112 ± 0	112 ± 0	112 ± 0	109 ± 9
MRT (day)	47 ± 1	48^c ± 4	43^c ± 6	20 ± 3
Cl (L/kg/day)	n/a	n/a	n/a	0.14 ± 0.02
V_z (L/kg)	n/a	n/a	n/a	3.1 ± 0.5
F (%)	22 ± 4	24 ± 4	25 ± 5	n/a

^aMedian, other values are mean ± standard deviation
^bData previously published in Kilp et al. [4]; ^cMean consits of n = 4 (50.0 mg/kg)/ n = 5 (25.0 mg/kg) values; other values excluded as considered unreliable; see Methods
n/a - not applicable

ISSN: 1756-3305