Table 1 Main arthropod protein candidates for TBVs to control arboviruses
From: Arbovirosis and potential transmission blocking vaccines
Candidate molecule | Arthropod host | Function | Effect on disease | Available as vaccine |
|---|---|---|---|---|
mosGCTL-1 | Aedes aegypti | Involved in WNV attachment by interacting with PTP-1 [65] | Reduces WNV infection in mosquitoes | No |
mosGCTL-3 | Aedes aegypti | Modulates virus entrance by interacting with the DENV Envelope protein [67] | Reduce DENV infection in mosquitoes | No |
CRVP-379 | Aedes aegypti | Interacts with the putative DENV receptor prohibitin [63, 102] | Blocks DENV infection in midgut | No |
CPB-1 | Aedes aegypti | Midgut antigen. Interacts with the DENV Envelope protein [100, 101] | Reduces DENV infection in mosquito | No |
64-TRP | Rhipicepalus appendiculatus | Salivary antigen. Secures ticks mouth parts during blood feeding [136, 137] | Reduces vector-host contact. Induces death of blood feed ticks | No |
Bm-86 | Rhipicephalus microplus | Reduces blood uptake and vector-host contact | Yes | |
PpChit-1 | Phlebotomus papatasi | Aids maturation of peritrophic matrix [159] | Reduced sand fly life span and fecundity | No |