Shifting the paradigm in Dirofilaria immitis prevention: blocking transmission from mosquitoes to dogs using repellents/insecticides and macrocyclic lactone prevention as part of a multimodal approach

Table 2 Study schedule

Study step	Study day
DPP^a administration in Groups 2 and 4	0
MBO^b administration in Groups 3 and 4	51
Body weight for randomization	–1
Microfilaremia + antigen test	–5		141
Exposure to infected mosquitoes	21	28
L3 counts in mosquitoes	21	28
Counts of worms in dogs (necropsy)				176^c-177

^a DPP dinotefuran permethrin pyriproxyfen (Vectra® 3D)
^b MBO milbemycin oxime (Interceptor®)
^cReplicate A dogs were necropsied on Study Day 177 and replicate B dogs were necropsied on Study Day 176

ISSN: 1756-3305