Table 1 Study 1, arithmetic (geometric) mean counts of live Ixodes holocyclus and efficacy at 72 h post treatment and after each infestation following a single treatment of dogs with fluralaner subcutaneous injection
Time after treatment | Mean live tick countsa arithmetic (geometric) | % efficacy, arithmetic (geometric) mean | Statistics | ||
|---|---|---|---|---|---|
Control | Fluralaner | t-value | P-value | ||
3 days (Week 0) | 19.8 (19.6) | 7.1 (5.3) | 64.1 (72.9) | t9 = 4.7 | 0.001 |
Week 1 | 17.7 (17.3) | 0.3 (0.2) | 98.3 (98.7) | t9 = 26.0 | < 0.001 |
Week 2 | 21.2 (21.0) | 0.4 (0.2) | 98.1 (98.8) | t9 = 20.3 | < 0.001 |
Week 5 | 21.0 (20.5) | 0.2 (0.1) | 99.0 (99.4) | t9 = 22.9 | < 0.001 |
Week 9 | 16.2 (15.5) | 0.0 (0.0) | 100.0 (100.0) | t9 = 27.2 | < 0.001 |
Week 13 | 18.5 (17.9) | 0.2 (0.1) | 98.9 (99.2) | t9 = 24.4 | < 0.001 |
Week 18 | 16.8 (16.1) | 0.2 (0.1) | 98.8 (99.1) | t9 = 24.3 | < 0.001 |
Week 22 | 16.4 (16.0) | 0.2 (0.1) | 98.8 (99.3) | t9 = 22.7 | < 0.001 |
Week 26 | 17.3 (16.7) | 0.1 (0.1) | 99.4 (99.6) | t9 = 27.9 | < 0.001 |
Week 30 | 17.8 (17.4) | 0.1 (0.1) | 99.4 (99.6) | t8 = 34.1 | < 0.001 |
Week 35 | 19.4 (19.2) | 0.2 (0.1) | 99.0 (99.2) | t9 = 32.3 | < 0.001 |
Week 39 | 16.4 (16.2) | 0.4 (0.3) | 97.6 (98.3) | t9 = 18.5 | < 0.001 |
Week 43 | 18.8 (18.5) | 0.8 (0.5) | 95.7 (97.3) | t9 = 13.1 | < 0.001 |
Week 48 | 21.6 (21.5) | 0.3 (0.2) | 98.6 (99.1) | t9 = 22.8 | < 0.001 |
Week 52 | 18.6 (18.1) | 0.3 (0.2) | 98.4 (98.7) | t9 = 20.8 | < 0.001 |
Week 57 | 18.1 (17.9) | 0.7 (0.5) | 96.1 (97.4) | t9 = 14.5 | < 0.001 |