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Fig. 6 | Parasites & Vectors

Fig. 6

From: csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis

Fig. 6

PTEN inhibited ICC proliferation and migration via a ferroptosis mechanism. a Stable PTEN overexpression (PTEN-EXO) or CRISPR/Cas9-based knockout (PTEN-KO) HuCCT1 cell lines were established; the scale shown is 100 um. b Cell proliferation was measured by CCK-8 assay in vitro. c Cell proliferation was measured by tumor xenograft in vivo. d Cell migration was measured by transwell assay. e Cell GSH/GSSG radio assay. f Cell Fe2+ assay. g Cell MDA assay. h, i Cell WB assay of SLC7A11 and GPX4. ICC, intrahepatic cholangiocarcinoma; WB, western blotting; GSH, glutathione; GSSG, GSH disulfide; MDA, malondialdehyde. *P < 0.05, **P < 0.01

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Parasites & Vectors

ISSN: 1756-3305

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