csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis

Table 1 Clinical and pathological characteristics of ICC patients with or without Clonorchis sinensis infection

Characteristics	CS-ICC (n = 46)	NC-ICC (n = 46)	P-value
Age, years	65.1 ± 9.5	66.3 ± 8.2	0.72
Sex, male	22	21	0.85
BMI, kg/m²	22.9 ± 2.8	22.3 ± 2.5	0.78
Length of stenosis, mm	25.7 ± 6.4	23.0 ± 7.9	0.33
Total bilirubin, mmol/l	260.1 ± 76.9	150.3 ± 69.8	< 0.05
Tumor location			0.68
Left IBD	26	24
Right IBD	20	22
Cancer stage by AJCC, 7th			< 0.05
I–II	14	24
III–IV	32	22
Tumor differentiation			< 0.05
Well/moderate	18	26
Poorly	28	20

Data are expressed as n or mean ± SD
ICC, intrahepatic cholangiocarcinoma; CS-ICC, ICC with Clonorchis sinensis infection; NC-ICC, ICC without Clonorchis sinensis infection; BMI, body mass index; IBD, intrahepatic bile duct; n, number of patients

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