Low diagnostic performance of thick blood smears of 50 µl in comparison with direct examination of 10 µl blood and the leukoconcentration technique of 5ml blood among loiasis-suspected patients with low microfilaremia in Gabon, Central Africa, using the STARD-BLCM guidelines

M’Bondoukwé, Noé Patrick; Owono-Medang, Matthieu; Moussavou-Boussougou, Marie Noëlle; Akoue, Yvan; Migueba, Valentin; Bulaev, Dmitry; Neven, Anouk; James, Luice Aurtin Joel; Ntsame Ella, Sylvie Alberte; Mawili-Mboumba, Denise Patricia; Atsame, Julienne; Vaillant, Michel; Bouyou Akotet, Marielle Karine

doi:10.1186/s13071-023-06089-1

Table 7 Diagnostic accuracy using Bayesian latent class analysis: BLCM model I

From: Low diagnostic performance of thick blood smears of 50 µl in comparison with direct examination of 10 µl blood and the leukoconcentration technique of 5ml blood among loiasis-suspected patients with low microfilaremia in Gabon, Central Africa, using the STARD-BLCM guidelines

Model I	Subgroups	Median (95% credible interval) (%)
Parasitological technique	Subgroups	Prevalence		Sensitivity		Specificity		Positive predictive value		Negative predictive value
Direct blood examination (10 µl)/thick blood smear (50 µl)	Global	9.7	6.2–13.7	78.9	65.3–90.3	100.0	99.3–100.0	99.1	87.2–100.0	93.0	87.3–97.7
	Age group
	15–64 years	8.8	5.1–13.0	76.3	62.4–90.0	99.9	99.2–100.0	99.1	86.7–100.0	93.0	87.3–97.7
	Other age groups^b
	Gender
	Male	11.3	5.5–17.7	73.3	56.2–87.3	99.9	98.6–100.0	99.1	86.8–100.0	93.0	87.3–97.6
	Female	8.4	4.6–12.6	75.7	61.0–88.9	99.9	99.1–100.0	99.1	86.9–100.0	93.0	87.2–97.6
	Symptomatology
	Symptoms^b
	Loiasis-related symptoms	9.1	4.6–14.6	72.3	56.4–87.5	99.9	98.9–100.0	99.1	86.5–100.0	93.0	87.2–97.6
	No symptoms	10.2	5.7–15.6	76.1	61.2–89.3	99.9	98.9–100.0	99.1	87.3–100.0	93.0	87.2–97.7
	Eosinophilia
	Normal	4.5	1.5–8.2	68.7	50.2–85.3	99.9	99.9–100.0	99.1	86.9–100.0	93.0	87.1–97.6
	Hypereosinophilia^b
Leukoconcentration(5 ml)^a	Global	9.7	6.2–13.7	99.9	97.8–100.0	91.4	88.6–94.1	74.1	66.0–81.7	99.9	98.8–100.0
	Age groups
	15–64 years	8.8	5.1–13.0	99.8	97.7–100.0	90.7	87.6–93.5	74.0	66.0–82.1	98.8	98.8–100.0
	Other age groups^b
	Gender
	Male	11.3	5.5–17.7	99.8	97.5–100.0	88.6	84.9–92.3	74.1	65.4–81.7	99.9	98.8–100.0
	Female	8.4	4.6–12.6	99.8	97.5–100.0	90.8	87.6–93.6	74.1	66.0–81.9	99.9	98.8–100.0
	Symptomatology
	Symptoms^b
	Loiasis-related symptoms	9.1	4.6–14.6	99.8	97.5–100.0	89.1	85.4–92.4	74.1	65.9–81.9	99.9	98.8–100.0
	No symptoms	10.2	5.7–15.6	99.8	97.4–100.0	90.1	86.7–93.3	74.1	66.1–82.2	99.9	98.8–100.0
	Eosinophilia
	Normal	4.5	1.5–8.2	99.8	97.2–100.0	90.2	86.9–93.4	74.1	65.8–81.7	99.9	98.8–100.0
	Hypereosinophilia^b

^aImperfect reference test
^bModel did not converge for this particular population subgroup

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