Pyrethroid resistance status and co-occurrence of V1016G, F1534C and S989P mutations in the Aedes aegypti population from two dengue outbreak counties along the China-Myanmar border

Chen, Li; Zhou, Kemei; Shi, Jun; Zheng, Yuting; Zhao, Xiaotao; Du, Qingyun; Lin, Yingkun; Yin, Xaioxiong; Jiang, Jinyong; Feng, Xinyu

doi:10.1186/s13071-024-06124-9

Table 3 Correlation between the kdr mutation types in Ae. aegypti from Ruili and Gengma counties with their resistance phenotypes to the three insecticides

From: Pyrethroid resistance status and co-occurrence of V1016G, F1534C and S989P mutations in the Aedes aegypti population from two dengue outbreak counties along the China-Myanmar border

Insecticide	Sampling site	Phenotype^a	Number of mosquitoes tested	Mutation type
				S989P + V1016G + F1534C			S989P + V1016G			V1016G + F1534C			V1016G
				Frequency, N (%)	OR (95% CI)	P value (Fisher’s exact test)	Frequency, N (%)	OR (95% CI)	P value (Fisher’s exact test)	Frequency, N (%)	OR (95% CI)	P value (Fisher’s exact test)	Frequency, N (%)	Statistical analysis
Permethrin (3.20%)	Ruili	R (Alive)	57	37 (64.9)	2.59 (0.73–9.22)	0.24	5 (8.8)	0.14 (0.03–0.59)	0.01*	15 (26.2)	1.79 (0.35–9.10)	0.74	0	_^b
	Ruili	S (Dead)	12	5 (41.7)	2.59 (0.73–9.22)	0.24	5 (41.7)	0.14 (0.03–0.59)	0.01*	2 (16.7)	1.79 (0.35–9.10)	0.74	0
	Gengma	R (Alive)	33	19 (57.6)	2.71 (0.43–16.96)	0.52	9 (27.3)	0.19 (0.03–1.21)	0.16	5 (15.2)	_	0.57	0
	Gengma	S (Dead)	6	2 (33.3)	2.71 (0.43–16.96)	0.52	4 (66.7)	0.19 (0.03–1.21)	0.16	0	_	0.57	0
Lambda cyhalothrin (0.08%)	Ruili	R (Alive)	60	39 (65.0)	1.48 (0.36–6.13)	0.86	6 (10.0)	_	1.00	15 (25.0)	0.42 (0.10–1.76)	0.41	0
	Ruili	S (Dead)	9	5 (55.6)	1.48 (0.36–6.13)	0.86	0	_	1.00	4 (44.4)	0.42 (0.10–1.76)	0.41	0
	Gengma	R (Alive)	60	40 (66.7)	2.86 (1.20–6.81)	0.02*	8 (13.3)	0.12 (0.04–0.33)	0.00*	12 (20.2)	_	0.01*	0
	Gengma	S (Dead)	34	14 (42.4)	2.86 (1.20–6.81)	0.02*	19 (57.6)	0.12 (0.04–0.33)	0.00*	0	_	0.01*	1(2.94)
Deltamethrin (0.20%)	Ruili	R (Alive)	53	36 (67.9)	0.81 (0.25–2.66)	0.73	3 (5.7)	0.21 (0.04–1.05)	0.11	14 (26.4)	6.10 (0.74–50.20)	0.12	0
	Ruili	S (Dead)	18	13 (72.8)	0.81 (0.25–2.66)	0.73	4 (22.2)	0.21 (0.04–1.05)	0.11	1 (5.6)	6.10 (0.74–50.20)	0.12	0
	Gengma	R (Alive)	0	0	_^b	_	0	_	_	0	_	_	0
	Gengma	S (Dead)	109	64 (58.7)	_^b	_	31 (28.4)	_	_	14 (12.8)	_	_	0
Total	Ruili	R (Alive)	170	112 (65.8)	1.34 (0.66–2.74)	0.42	14 (8.2)	0.30 (0.12–0.75)	0.02*	44 (25.9)	1.59 (0.66–3.88)	0.30	0
	Ruili	S (Dead)	39	23 (59.0)	1.34 (0.66–2.74)	0.42	9 (23.1)	0.30 (0.12–0.75)	0.02*	7 (18.0)	1.59 (0.66–3.88)	0.30	0
	Gengma	R (Alive)	93	59 (63.4)	1.50 (0.88–2.55)	0.14	17 (18.3)	0.39 (0.21–0.73)	0.00*	17 (18.3)	2.16 (1.01–4.62)	0.04*	0
	Gengma	S (Dead)	149	80 (54.1)	1.50 (0.88–2.55)	0.14	54 (36.5)	0.39 (0.21–0.73)	0.00*	14(9.5)	2.16 (1.01–4.62)	0.04*	1(0.67)

CI Confidence interval, OR odds ratio
*Statistically significant difference at P < 0.05
^aS indicates susceptible, based on mortality rate of ≥ 98%; R indicates resistance, based on a mortality rate < 90%
^b–, Not determined

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ISSN: 1756-3305

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