Table 2 Diagnostic performance of the Ov-RPA–CRISPR/Cas12a assay based on the fluorescence values for detecting O. viverrini infection in field-collected fecal samples (n = 121) compared with standard methods (KK and/or FECT methods)
Diagnostic performance of the Ov-RPA–CRISPR/Cas12a assay | Value | 95% CI |
|---|---|---|
Sensitivity | 62.1% | 42.3–79.3% |
Specificity | 89.1% | 81.0–94.7% |
Positive likelihood ratio (LR+) | 5.7 | 3.0–11.0 |
Negative likelihood ratio (LR−) | 0.4 | 0.3–0.7 |
Positive predictive value (PPV) | 85.1% | 74.9–91.6% |
Negative predictive value (NPV) | 70.2% | 59.5–79.0% |
Accuracy | 75.6% | 67.0–83.0% |