Fig. 5
From: Toxoplasma sortilin interacts with secretory proteins and it is critical for parasite proliferation
The sortilin inhibitor AF38469 inhibited parasite invasion, proliferation, and infectivity of T. gondii. A–C Toxoplasma gondii invasion and replication rates were reduced by AF38469 in vitro, but the egress rate was not affected. Drug concentrations were set to 0, 75, 150, 300, 500, and 1000 nM. DMSO was used as a negative control. Error bars represent the mean ± SD (n = 3). **P < 0.01. D Mouse survival time was prolonged by oral administration of 500 nM AF38469. Each mouse was infected intraperitoneally with 100 T. gondii tachyzoites. DMSO and PBS were used as negative controls. E Toxoplasma gondii intracellular growth was inhibited by AF38469 in plaque assays. Drug concentrations were set to 0, 75, 150, 300, 500, and 1000 nM