Fig. 6
From: Toxoplasma sortilin interacts with secretory proteins and it is critical for parasite proliferation
The Vps10 subdomain was found to interact with the sortilin inhibitor AF38469. A–H The Vps10 subdomain showed a significant affinity for AF38469 in a concentration-dependent manner and formed a better static curve, but sortilin-N, sortilin-C, and sortilin-M did not. DMSO was used as a negative control. I Binding position of the inhibitor AF38469 (red arrow) to the Vps10 subdomain (green) in the 3D structure. J The simulated binding site of the inhibitor AF38469 to the Vps10 subdomain was located at lysine (Lys352) and tyrosine (Tyr399)