Figure 4

Scheme of biological cycle of Trypanosoma rangeli within its insect vector. The insect feeds on blood infected with trypomastigote forms which differentiate to epimastigotes in the midgut (white arrows) where they multiply (1). Some epimastigotes invade the hemolymph through the gut epithelium (red arrow). Long and short forms of epimastigotes can entry into the hemocytes and multiply or replicate in the plasma (2). Some parasites invade the salivary glands (blue arrow) and differentiate to trypomastigotes which will be transmitted when the insect-vector feeds on another host (3).