Skip to main content

Advertisement

Table 1 Factors involved in translocation of proteins across the ER membrane and their relationship to SLS

From: Spliced leader RNA silencing (SLS) - a programmed cell death pathway in Trypanosoma brucei that is induced upon ER stress

Factor SRP54 SRa SEC61 SEC63 SEC71
Function One of the SRP proteins recognizes the signal peptide SRP receptor localized on the ER membrane The translocon localized in the ER membrane Factor essential for co- and post translational translocation Factor essential exclusively for post-translation translocation
Translocation defects in RNAi-silenced cells Mislocalization of SP-proteins, no production of membrane proteins Mislocalization of SP-proteins, no production of membrane proteins Mislocalization of SP-proteins, no production of membrane proteins Mislocalization of SP-proteins, no production of membrane proteins Mislocalization of SP-proteins, reduction in GPI-anchored proteins, no effect on membrane proteins
Induction of SLS No YES YES YES NO
  1. The data is based on [2, 8, 9, 56].