Gene expression profile suggests that pigs (Sus scrofa) are susceptible to Anaplasma phagocytophilum but control infection

Table 3 Gene ontology enrichment analysis of genes differentially expressed in wild pigs naturally infected with A. phagocytophilum

GO category	Represented on the microarray (%)^a	Represented among differentially expressed genes (%)^b
Molecular function
Cation binding	67 (2.4)	5 (15.6)*
Protein binding	14 (0.5)	20 (62.5)*
Transcription factor	10 (0.4)	5 (15.6)*
Receptor activity	10 (0.4)	8 (25.0)*
Biological process
Catabolic process	108 (3.8)	3 (9.4)*
Immune response	23 (0.8)	4 (12.5)*
Cell adhesion	20 (0.7)	8 (25.0)*
Signaling pathway	13 (0.5)	10 (31.2)*
Cell differentiation	7 (0.2)	3 (9.4)*

^aOf the 20,201 S. scrofa genes analyzed in the microarray, 2,840 had GO assignments and were used for GO enrichment analysis.
^bOf the 61 genes that showed significant (P ≤ 0.05) ≥ 2 fold changes in expression in infected wild pigs, 32 had GO assignments and were used for GO enrichment analysis. For genes with multiple GO assignments, each category was included in the analysis. For each GO category of interest, entries in the array were compared with results of differentially expressed genes by χ 2–test (*α < 0.01).

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