Figure 3

Overt cytopathic effects associated with Rabensburg virus growth on Aedes albopictus cells incubated at 28°C. At three days post inoculation extensive cell fusion, giant multi-nucleated cells, and syncytia formation are evident in C6/36 cells infected with Rabensburg virus strains 97–103 and 06–222 (A, B). No obvious pathology was observed in cells infected with West Nile virus strain WN02-1956 (C) or in mock inoculated cells (D) three days post inoculation. Cell fusion, yellow arrows; *, giant cells; A-D scale bar, 100 μm.