The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization

Table 1 Recovery rate and localization of larvae recovered from different organs of knockout BALB/C mice experimentally infected with human Loa loa.

Strain	No. of animal dissected	No. of larvae recovered	Subcutaneous tissue	Muscle	Genital organ	Peritoneal cavity	Pleural cavity	Heart and Lungs	Statistics
IL-4 R-α	14	80	23(28.75)	49(61.25)	5(6.25)	2(2.50)	1(1.25)	0	-
INF-γ KO	34	430	296(68.84)	73(16.98)	14(3.26)	25(5.81)	16(3.72)	6(1.40)	χ² = 1058.92 p = 0.0001
IL-5 KO	48	524	254(48.47)	207(39.50)	9(1.72)	34(6.49)	14(2.67)	6(1.15)	χ² = 866.30 p = 0.0001
INF-γ/IL-5 DKO	23	283	137(48.41)	112(39.58)	3(1.06)	23(8.13)	7(2.47)	1(0.35)	χ² = 472.02 p = 0.0001
IL-4/IL-5 D KO	27	439	174(39.64)	190(43.28)	5(1.14)	31(7.06)	29(6.61)	10(2.28)	χ² = 593.43 p = 0.0001
Statistics			χ² = 95.12 P = 0.0001	χ² = 104.13 P = 0.0001	χ² = 13.64 P = 0.0001	χ² = 3.87 P = 042	χ² = 14.04 P = 0.007	-

Each mouse was inoculated with 100 L3 of L. loa. The figures in brackets are the percentages of larvae recovered.

ISSN: 1756-3305