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Table 1 The results of 5 independent experiments are summarised

From: The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats

Trial 100 nM Imidacloprid 50 nM Flumethrin 100 nM Imidacloprid + 50 nM Flumethrin Synergism
Trial Amp[μV] cps Amp[μV] cps Amp[μV] cps  
05-05 75 75 - 5 150 100 ++
21-05a 50 58 - 5 100 89 ++
21-05b 50 75 - 10 70 100 ++
25-05a 50 80 10 40 100 90 +/-
25-05b 70 50 - 10 100 80 ++
mean 59 67.1 - 14 104 91.8  
SD 12.45 12.9 - 14.75 28.81 8.44  
P* [vs combination of Flu/Imi] 0.009 0.003 na 0.0007 - -  
  1. The isolated nerve cord fibres of Spodoptera frugiperda were stimulated with 100 nM imidacloprid, 50 nM flumethrin and then a combination of these two compounds and the amplitude of nerve discharge and the number of discharges (counts per second, cps) are given. Imidacloprid alone had a modest effect, flumethrin alone had a negligible effect and the combination of both compounds together demonstrate a clearly synergistic effect well in excess of what either compound alone induced
  2. * Normality and two-sided paired t-test was perfomed for all data from five trials using SigmaPlot for Windows 11.0 (Build 11.0.0.75, © 2008 Systat Software, Inc.)