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Table 2 The dose response curve showing mean % mortality and efficacy of flumethrin or imidacloprid or a 1: 1.85 combination of flumethrin and imidacloprid coating on glass vial surfaces (mean data from 2 separate trials) against Ctenocephalides felis fleas

From: The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats

  Imidacloprid: Flumethrin 1.85: 1 Flumethrin Imidacloprid
[μg/cm 2 ] 24 h 48 h 24 h 48 h 24 h 48 h
  Mortality Efficacy Mortality Efficacy Mortality Efficacy Mortality Efficacy Mortality Efficacy Mortality Efficacy
5 100 100 100 100 75 100 100 100 30 100 100 100
1 100 100 100 100 60 100 80 100 25 90 100 100
0,2 80 100 100 100 40 100 70 100 0 60 80 100
0,04 40 80 60 100 30 60 60 100 0 30 40 100
0,008 0 30 30 60 0 0 0 40 0 0 0 0
0,0016 0 0 0 0 0 0 0 0 0 0 0 0
0,00032 0 0 0 0 0 0 0 0 0 0 0 0
0,000064 0 0 0 0 0 0 0 0 0 0 0 0
min -1,582 -2,287 -0,078 -0,011 -4,929 -1,243 -3,390 0,031 -1,531 -0,914 -1,752 -0,012
max 100,5 100,4 103,8 100,0 100,0 99,9 93,7 100,0 100,0 101,0 106,0 100,0
ED50 μg/cm2 0,059 0,012 0,033 0,008 0,483 0,010 0,039 0,009 0,537 0,074 0,112 0,017
Slope 1,296 1,285 1,111 3,889 0,363 1,736 1,031 4,006 17,378 1,433 0,937 3,315
ED50 Factor (FI = 1)      8,2 0,9 1,2 1,2 9,1 6,4 3,4 2,3
Normality* Test (Shapiro-Wilk) Passed Passed Passed Passed Passed Passed Passed Passed Passed Failed Passed Passed
P-values* 24 h mortality vs untreated control 0.028     0.004     0.0457    
P-values* FI vs F or I -     0.0094     -0.0024    
P-values* F vs I -     -     -0.0027    
  1. * Normality and two-sided paired t-test was perfomed for data used in Figure 4 with all data from both trials, means of the two trials were used for curve fitting and fit statistics using SigmaPlot for Windows 11.0 (Build 11.0.0.75, © 2008 Systat Software, Inc.)