Table 4 KEGG analysis of the target genes of the differentially expressed miRNAs in different tissues of Wistar rats following S.japonicum infection
Category | Term | Genes | P value |
|---|---|---|---|
mmu-miR-346* | Focal adhesion | CAV1, PDGFB, FLT4, ACTN1, ITGA3, COL5A3, PPP1CB, HRAS1, AKT1, LAMA4, CCND2, ITGB8, GSK3B, COL6A2, PDGFRB, COL1A1, PARVB, DIAP1 | 2.37E-04 |
MAPK signaling pathway | FGFR4, PDGFB, CACNB1, MKNK2, TGFB3, CACNG2, CACNG1, SRF, CACNA2D2, HRAS1, AKT1, DUSP3, RPS6KA2, IKBKG, PPP3CC, PDGFRB, PRKACB, TRAF6, MAP2K6 | 2.38E-03 | |
Long-term potentiation | ADCY1, RPS6KA2, CALM3, PPP3CC, PRKACB, CAMK2A, PPP1CB, HRAS1 | 8.39E-03 | |
rno-miR-3584-5p | Wnt signaling pathway | PPP2R1B, PPP2R5B, APC2, MAP3K7, SFRP5, RAC2, PRICKLE1, NFAT5, LRP6, CAMK2B, RHOC, PPP2R5E, NFATC2, FOSL1, WNT8B | 4.27E-03 |
Neurotrophin signaling pathway | IRAK2, PDK1, MAPK11, IRS1, YWHAE, TP73, MAP3K3, SORT1, RAP1A, CAMK2B, RHOC, NGFR, ARHGDIB | 8.81E-03 | |
Axon guidance | NRP1, EFNB3, DPYSL5, EPHB1, EPHB6, RAC2, SEMA4G, NFAT5, SEMA3B, RHOC, EFNA4, NFATC2, SEMA4A | 9.36E-03 | |
rno-miR-328* | MAPK signaling pathway | TAOK1, TGFBR1, RELA, CACNB1, MKNK2, TGFB3, MKNK1, CACNG2, CACNG1, AKT1, DUSP3, MAP3K3, DUSP14, RPS6KA2, PPP3CB, MAPK9, PDGFRB, CACNA1E, RASA1, MAP3K11 | 3.52E-08 |
Dilated cardiomyopathy | ADCY1, ADCY9, ITGA5, TGFB3, CACNB1, CACNG2, CACNG1 | 3.79E-03 | |
Focal adhesion | AKT1, CCND2, ITGA5, FLT4, COL6A2, PDGFRB, MAPK9, COL5A3, PARVB, DIAP1 | 4.87E-03 | |
Axon guidance | ABLIM2, NRAS, PAK7, SEMA4G, LIMK2, EFNB1, NFAT5, L1CAM, PAK1, CHP, EPHB3, SRGAP2 | 1.02E-05 | |
T cell receptor signaling pathway | NRAS, PAK7, RASGRP1, PIK3CD, NFAT5, MAPK9, PAK1, CHP | 2.68E-03 | |
Wnt signaling pathway | WNT1, CCND1, PRICKLE1, VANGL2, LRP6, NFAT5, MAPK9, CHP, FZD4 | 3.48E-03 | |
Neurotrophin signaling pathway | IRAK1, NRAS, IRS3, NTF4, PIK3CD, MAPK9, FRS2, PRKCD | 5.99E-03 | |
mmu-miR-466j | Cell adhesion molecules (CAMs) | CD274, CD4, CDH1, CDH2, CD28, CLDN15 | 8.82E-03 |
mmu-miR-1895 | Chemokine signaling pathway | BRAF, TIAM1, RHOA, GRK6, JAK2, SHC2 | 4.55E-03 |
mmu-miR-3095-3p | mTOR signaling pathway | RPS6KA2, ULK2, PIK3R5, RPTOR | 6.53E-03 |
mmu-miR-3072* | Neurotrophin signaling pathway | PDK1, IRAK3, RPS6KA1, RPS6KA2, GRB2, MAPK14, PIK3R5, SHC2, HRAS1 | 4.12E-04 |
Fc epsilon RI signaling pathway | PDK1, GRB2, MAPK14, IL13, PIK3R5, HRAS1 | 5.48E-03 | |
Focal adhesion | VEGFB, CCND2, GRB2, COMP, COL6A2, PIK3R5, SHC2, MYLK, HRAS1 | 6.01E-03 | |
mTOR signaling pathway | VEGFB, RPS6KA1, RPS6KA2, RPS6KB2, PIK3R5 | 6.53E-03 | |
mmu-miR-5112 | Melanogenesis | GNAQ, ADCY8, CREB1, PRKACA, WNT9A, PRKACB | 2.34E-03 |