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Risk:Benefit
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Must be very high Parasitological cure must be achieved
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No direct associated mortality with symptomatic treatment
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Ease of use
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Feasible to use at the level of a health clinic
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Course of treatment
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Very short course of treatment to facilitate compliance
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Minimum acceptable treatment for children: one week (similar to antibiotics)
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Cold chain requirements
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Ideally not cold chain dependent
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Cost factors
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Cost is less important than commitment to treatment
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Concomitant infections
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With HIV co-infection, no antimonials or monotherapies
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