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Table 1 Regional target product profiles
| Target profile | South Asia | Africa |
|---|---|---|
| Risk:Benefit | Must be very high Parasitological cure must be achieved | No direct associated mortality with symptomatic treatment |
| Ease of use | Feasible to use at the level of a health clinic | |
| Course of treatment | Very short course of treatment to facilitate compliance | Minimum acceptable treatment for children: one week (similar to antibiotics) |
| Cold chain requirements | Ideally not cold chain dependent | |
| Cost factors | Cost is less important than commitment to treatment | |
| Concomitant infections | With HIV co-infection, no antimonials or monotherapies |
