Figure 4

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-R) sequence analysis. Sequence alignment of Culex quinquefasciatus (Cq), Aedes aegypti (Aa), and L. longipalpis (LLphg-contig_215) HMG-R. Identical residues are highlighted in black and similar residues highlighted in gray (>70%). The illustrated sequences represent a subset of this alignment and include residues that extend from positions four hundred to seven hundred. The predicted HMG-CoA binding motif (ENVIG) is shown in the blue box and the predicted NADP(H) binding motif (DAMGXN) is shown in the green box. The accession numbers of the sequences used are between parentheses.