miR-454 mimics could inhibit TGF-β1–induced α-SMA expression in LX-2 cells. (A) miR-454 mimics reduced the levels of α-SMA mRNA expression in TGF-β1-treated LX-2 cells as detected by qRT-PCR. * P <0.05 vs control (cells with no stimulus). # P <0.05 vs the group of TGF-β1 + mimics+. (B) Western blot analysis confirmed that α-SMA protein expression was inhibited by miR-454 mimics in TGF-β1-treated LX-2 cells.