Table 3 Transmission blocking activity: dose dependent efficacy of NeemAzal® (NA) on Plasmodium falciparum oocyst prevalence and density
Blood sample number | Gametocytes per μL blood | Treatment and concentration | Prevalence of infected mosquitoes% (infected/total examined) | Mean number of oocysts/mosquito (CI95) |
|---|---|---|---|---|
11 | 400 | control | 64 (09/14) | 51.36 (12.83-89.88) |
NA 70 ppm | 0 (0/25) | 0.00 | ||
12 | 1760 | control | 75 (12/16) | 94.38 (38.29-150.46) |
NA 70 ppm | 0 (00/25) | 0.00 | ||
17 | 112 | control | 80 (12/15) | 4.53 (2.69-6.38) |
NA 60 ppm | 0 (0/31) | 0.00 | ||
16 | 184 | control | 64 (29/45) | 4.58 (2.96-6.19) |
NA 60 ppm | 0 (0/56) | 0.00 | ||
15 | 344 | control | 90 (09/10) | 131.00 (49.69-212.31) |
NA 60 ppm | 12 (03/25) | 0.36 (0.00-0.83) | ||
11 | 400 | control | 68 (17/25) | 49.36 (22.92-75.80) |
NA 60 ppm | 0 (0/25) | 0.00 | ||
12 | 1760 | control | 75 (12/16) | 94.38 (38.29-150.46) |
NA 60 ppm | 0 (0/25) | 0.00 | ||
17 | 112 | control | 85 (11/13) | 3.92 (1.91-5.93) |
NA 50 ppm | 23 (07/31) | 0.35 (0.05-0.66) | ||
16 | 184 | control | 59 (24/41) | 2.68 (1.58-3.79) |
NA 50 ppm | 0 (0/46) | 0.00 | ||
15 | 344 | control | 92 (24/26) | 151.58 (97.31-205.84) |
NA 50 ppm | 36 (15/42) | 2.29 (0.60-3.97) | ||
11 | 400 | control | 82 (28/34) | 66.50 (44.04-88.96) |
NA 50 ppm | 0 (0/23) | 0.00 | ||
6 | 528 | control | 90 (54/60) | 42.85 (31.36-54.34) |
NA 50 ppm | 18 (11/61) | 0.30 (0.10-0.49) | ||
17 | 112 | control | 67 (18/27) | 6.56 (3.60-9.51) |
NA 20 ppm | 52 (12/23) | 2.57 (0.86-4.27) | ||
16 | 184 | control | 84 (38/45) | 4.42 (2.92-5.93) |
NA 20 ppm | 41 (26/63) | 0.95 (0.56-1.34) | ||
15 | 344 | control | 81 (29/36) | 92.69 (47.92-137.46) |
NA 20 ppm | 60 (12/20) | 44.85 (7.90-81.80) | ||
6 | 528 | control | 85 (44/52) | 32.90 (22.36-43.45) |
NA 20 ppm | 88 (44/50) | 27.24 (19.12-35.36) |