Table 2 Inhibition of L. donovani L GSK-3 and L. mexicana L CRK3 by compounds 11–17
|  | IC50(μM) | |
|---|---|---|
Compounds | L GSK-3 | L CRK3 |
6-BIO | 0.15 ± 0.06 | 0.02 ± 0.01 |
5-Me-6-BIO | 0.09 ± 0.02 | 0.65 ± 0.09 |
11 | 0.10 ± 0.07 | >3.33 |
12 | 0.20 ± 0.08 | 0.99 ± 0.19 |
13 | 1.65 ± 0.17 | >3.33 |
14 | 1.95 ± 0.11 | >3.33 |
15 | 0.17 ± 0.25 | 0.14 ± 0.06 |
16 | 0.36 ± 0.18 | >3.33 |
17 | 0.88 ± 0.26 | >3.33 |