Figure 2

Phylogenetic trees displaying the relationships of GPCRs representing subclasses of class A, and also classes B and F identified in Schistosoma haematobium and S. mansoni. In each tree, the amino acid changes per site are shown. The posterior probability (pp) of each node is indicated by small circles (pp = 0.7-0.8) or dots (pp > 0.8) at nodes. Medium to high transcription (cf. Methods section) in the adult stages of the schistosomes is identified by asterisks. The class A amine tree shows the SVM sub-classification, coloured according to ligand affinity. Asterisks indicate experimentally validated GPCRs. Relationships of the sequences representing the SmGPR clade [23] (inset a shows an enlargement). Shae and Smp are codes for sequences from S. haematobium and S. mansoni, respectively.