Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment

Table 5 Adult flea emergence control after parent fleas fed on blood containing fluralaner at sub-insectcidal concentrations

Fluralaner (ng/mL)	Adult flea emergence control (%)
Fluralaner (ng/mL)	Exposure day^a
	3	4	5	8	9	10	Mean^b
50.0	NA	NA	NA	NA	NA	NA	NA
25.0	NA	NA	NA	NA	NA	NA	NA
12.5	NA	NA	NA	100	NA	NA	100
6.25	29.2	0	0	9.2	30.8	0	11.5
3.13	4.4	11.9	3.2	8.6	7.5	0	5.9
1.56	0	0	0	10.2	0	0	1.7
0.78	3.8	0	0	3.1	1.8	0	1.5
0.39	0	0	0	1.6	5.2	0	1.1
0.19	4.6	0	1.3	0.8	6.7	0	2.2
0.09	1.1	0.5	0	0	0	0	0.3

^aNo adult flea counts were performed on exposure days 6 and 7.
^bArithmetic mean.
NA: not applicable because fleas were either killed or did not lay eggs (Table 1, Table 2, and Table 4).

ISSN: 1756-3305