Figure 8
From: The pathogenesis of optic neuritis caused by Angiostrongylus cantonensis in BALB/c mice
TBD promotes RGC survival of mice infected with A. cantonensis . (A) RGC cells from normal controls labeled with BDA (B) Representative whole-mount area at three-sixths of the retinal radius. On day 17 after infection, RGCs in untreated eyes are labelled with BDA. (C) After treatment with TBD for 3 d, there was no obvious difference compared to the untreated group. (D) Infection for 21 d without treatment. The RGCs induced much less than control. (E) After treatment with TBD for 7 d, the number of RGCs increased compared to the untreated group (D). (F) Infection for 28 d without treatment. The RGCs induced much less than control (G). After treatment with TBD for 14 d, the number of RGCs increased compared to the group without treatment (F). (H) Data are mean ± SEM for retinal thickness with or without TBD treatment for 3 d, 7 d, and 14 d, respectively. *Statistically significant when compared with control (0 d infection); #Statistically significant when compared to untreated groups (P < 0.05).