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Table 2 Components of the insect Toll pathway identified in the C. sonorensis transcriptome

From: Gene discovery and differential expression analysis of humoral immune response elements in female Culicoides sonorensis (Diptera: Ceratopogonidae)

Description

Acc. no.

Seq. no.

Aedes Hit

Culex Hit

e-Value

Commentsa

Upstream signaling

      

Peptidoglycan Recognition Protein (Short); PGRP-SA

GAWM01018051

m.7996

AAEL009474

CPIJ007162

6.18e-17

Complete; PGRP amidase domain, signal AA 1-20

Gram-Negative Binding Protein (GNBP), or Beta-1,3-Glucan Binding Protein (BGBP); GNBP-1

GAWM01002165

m.15449

AAEL009176

CPIJ004321

3.81e-90

Complete; glycoside hydrolase, glucanase domains; signal AA 1-20

GNBP-1/BGBP-1

GAWM01003712

m.20067

AAEL009176

CPIJ004324

3.81e-90

Complete; glycoside hydrolase, glucanase domains; signal AA 1-29

GNBP-1/BGBP-1

GAWM01004143

m.21344

AAEL009176

CPIJ004321

3.81e-90

Complete; glycoside hydrolase, glucanase domains; signal AA 1-16

GNBP-3/BGBP-3

GAWM01011997

m.46772

AAEL000652

CPIJ013556

2.96e-38

Complete; GNBP domain, signal AA 1-25

Spaetzle-like cytokine, Spz3

GAWM01001358

m.13389

AAEL014950

CPIJ001752

3.56e-129

Putative, no signal

Spaetzle-like cytokine, Spz5

GAWM01006049

m.2718

AAEL001929

CPIJ009906

1.29e-44

Putative, no signal

Spaetzle-like cytokine, Spz6

GAWM01012721

m.49435

AAEL012164

CPIJ002281

2.42e-37

Truncated, no signal

Spaetzle-like cytokine, Spz1?

GAWM01015015

m.58907

AAEL000499

CPIJ014270

1.59e-35

Complete; either Spz1A or 1B; signal AA 1-31

Receptors

      

Toll receptor

GAWM01015594

m.61585

AAEL009551

CPIJ013183

5.73e-106

Possible toll; LRR/TIR but no flanking CRRs

Toll receptor

GAWM01019001

m.9915

AAEL000633

CPIJ019764

0

Possible toll; LRR/TIR but no flanking CRRs

Toll receptor

GAWM01015706

m.62033

AAEL009551

CPIJ008497

4.24e-152

Complete toll (LRR, flanking CRR, TIR)

Toll receptor

GAWM01013057

m.50841

AAEL002583

CPIJ016598

0

Complete toll (LRR, flanking CRR, TIR)

Toll receptor

GAWM01013058

m.50847

AAEL002583

CPIJ016598

0

Complete toll (LRR, flanking CRR, TIR)

Cell signaling

      

myeloid differentiation primary response protein 88 (MYD88)

GAWM01018790

m.948

AAEL007768

CPIJ018307

1.44e-46

Complete; death domain (DD), TIR domain

Ser/Thr Kinase, Pelle (IRAK1)

GAWM01001221

m.12898

AAEL006571

CPIJ015474

1.62e-92

Complete; N terminal DD and C terminal kinase

Ser/Thr Kinase, Pelle (IRAK1)

GAWM01011117

m.42913

AAEL006571

CPIJ015474

1.62e-92

Complete; N terminal DD and C terminal kinase

Tube (IRAK4)

GAWM01007838

m.32196

AAEL007642

CPIJ013746

1.93e-42

Complete; similar to other nematocera, Cs Tube has death domain and kinase domain with RD motif

cactus (IkappaB)

GAWM01009580

m.37494

AAEL001584

CPIJ004774

1.95e-16

Complete; ankyrin repeats AA 119-356

Transcription

      

dorsal/dif (REL1)b

GAWM01010293

m.40244

AAEL014821

CPIJ801839

4.73e-95

Complete; confirmed to have N-terminal rel homology domain and C-terminal IPT domain

dorsal/dif (REL1)

GAWM01010294

m.40249

AAEL014821

CPIJ801839

4.73e-95

Complete; confirmed to have N-terminal rel homology domain and C-terminal IPT domain

dorsal/dif (REL1)

GAWM01010296

m.40254

AAEL014821

CPIJ801839

4.73e-95

Complete; confirmed to have N-terminal rel homology domain and C-terminal IPT domain

dorsal/dif (REL1)

GAWM01010297

m.40255

AAEL014821

CPIJ801839

4.73e-95

Complete; confirmed to have N-terminal rel homology domain and C-terminal IPT domain

  1. aAA, amino acids; LRR, leucine rich region; CRR, cysteine rich region; TIR, Toll/interleukin-1 receptor domain; IPT, Ig-like, plexins, transcription factor domain.
  2. bmost likely only two of these unigene sequences are true paralogs, but due to the conserved RHD and IPT domains the assembly could not delineate during annotation.
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Parasites & Vectors

ISSN: 1756-3305

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