Immediate efficacy and persistent speed of kill of a novel oral formulation of afoxolaner (NexGardTM) against induced infestations with Ixodes ricinus ticks

Table 1 Geometric means of live female tick counts at the scheduled hours following treatment and further induced infestations

Days of tick count	Day 0		Day 7		Day 14		Day 21		Day 28
Hours of tick counts¹	12 h	24 h	12 h	24 h	12 h	24 h	12 h	24 h	12 h	24 h
Number of ticks²	14.5	16.4	20.8	24.4	22.4	21.8	19.1	21.2	19.9	19.3
Untreated Control Group	14.5	16.4	20.8	24.4	22.4	21.8	19.1	21.2	19.9	19.3
Number of ticks²	1.0	0.0	4.9	0.0	13.0	0.1	12.1	0.7	12.2	1.7
Treated Group (NexGard^TM)	1.0	0.0	4.9	0.0	13.0	0.1	12.1	0.7	12.2	1.7
% Efficacy ³	93.4**	100.0**	76.6*	100.0**	41.9	99.4**	36.9*	96.6*	38.5	91.2**

¹Hours of tick counts are indicated either post-treatment on D0 or post-infestation on days 7, 14, 21, 28.
²Geometric means tick counts.
³Based on Geometric means.
Treated Group differed statistically significantly from the untreated control Group with:
*(p < 0.05).
**(p < 0.01).

ISSN: 1756-3305