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Table 3 Clinical pathology parameters analyzed and mean results of day 162 for the control group and the fluralaner 5X group

From: Safety of fluralaner chewable tablets (BravectoTM), a novel systemic antiparasitic drug, in dogs after oral administration

  Parameter (unit) Control fluralaner 5X
Hematology Basophils (x 10^9/L) 0.175 0.171
  Eosinophils (x 10^9/L) 0.368 0.748
  Hematocrit (L/L) 0.476 0.451
  Hemoglobin (g/dL) 15.24 14.29
  Large unclassified cells (x 10^9/L) 0.04 0.06
  Lymphocytes (x 10^9/L) 3.81 4.13
  Mean corpuscular hemoglobin (pg) 21.01 21.26
  Mean corpuscular hemoglobin concentration (g/dL) 31.99 31.65
  Mean corpuscular volume (fL) 65.69 67.14
  Monocytes (x 10^9/L) 0.56 0.60
  Neutrophils (x 10^9/L) 6.67 6.65
  Platelets (x 10^9/L) 506 536
  Red blood cells (x 10^12/L) 7.24 6.74
  Reticulocytes (x 10^9/L) 70.8 53.3
  Total white blood cells (x 10^9/L) 11.62 12.34
Coagulation Activated partial thromboplastin time (s) 12.78 13.59
  Fibrinogen (mg/dL) 128.3 172.0
  Prothrombin time (s) 6.08 6.16
Clinical Adrenocorticotrophic hormone (pg/mL) 32.89 34.68
chemistry Alanine aminotransferase (U/L) 41.9 39.3
  Albumin (g/L) 34.75 33.13
  Albumin/globulin ratio 1.96 1.65
  Alkaline phosphatase (U/L) 70.50 72.00
  Amylase (U/L) 900 800
  Aspartate aminotransferase (U/L) 37.63 35.75
  Calcium (mmol/L) 2.77 2.76
  Chloride (mmol/L) 113.50 115.13
  Cholesterol (mmol/L) 5.96 5.68
  Creatine kinase (U/L) 306.5 223.4
  Creatinine (μmol/L) 54.25 50.50
  C-reactive protein (μg/mL) 3.84 10.16
  Gamma glutamyl transpeptidase (U/L) 3.50 3.13
  Globulin (g/L) 18.13 20.38
  Glucose (mmol/L) 6.24 6.24
  Inorganic phosphate (mmol/L) 2.14 2.14
  Lactate dehydrogenase (U/L) 32.50 23.88
  Magnesium (mmol/L) 0.69 0.71
  Phospholipid (mmol/L) 6.03 5.83
  Potassium (mmol/L) 4.75 4.75
  Sodium (mmol/L) 148.6 147.8
  Total bile acids (μmol/L) 5.98 4.51
  Total bilirubin (μmol/L) 1.78 2.10
  Total protein (g/L) 52.88 53.38
  Triglycerides (mmol/L) 0.44 0.34
  Urea (mmol/L) 5.20 4.08
Urinalysis Bilirubin (mg/dL), ketones (mg/dL), glucose (mg/dL), turbidity 0 0
  Blood pigments (mg/dL) 0.029 0.004
  Leukocytes (cells/μL) 150 106
  pH 6.44 6.44
  Protein (mg/dL) 8.75 5.00
  Specific gravity 1.031 1.025
  Urobilinogen (mg/dL) 0.40 0.20
  Volume (mL) 133 153
  Urine color Light yellow - yellow
  Microscopic examination (crystals, casts, red blood cells, white blood cells, epithelial cells, bacteria, other abnormalities) Similar frequency distribution