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Table 3 Clinical pathology parameters analyzed and mean results of day 162 for the control group and the fluralaner 5X group

From: Safety of fluralaner chewable tablets (BravectoTM), a novel systemic antiparasitic drug, in dogs after oral administration

 

Parameter (unit)

Control

fluralaner 5X

Hematology

Basophils (x 10^9/L)

0.175

0.171

 

Eosinophils (x 10^9/L)

0.368

0.748

 

Hematocrit (L/L)

0.476

0.451

 

Hemoglobin (g/dL)

15.24

14.29

 

Large unclassified cells (x 10^9/L)

0.04

0.06

 

Lymphocytes (x 10^9/L)

3.81

4.13

 

Mean corpuscular hemoglobin (pg)

21.01

21.26

 

Mean corpuscular hemoglobin concentration (g/dL)

31.99

31.65

 

Mean corpuscular volume (fL)

65.69

67.14

 

Monocytes (x 10^9/L)

0.56

0.60

 

Neutrophils (x 10^9/L)

6.67

6.65

 

Platelets (x 10^9/L)

506

536

 

Red blood cells (x 10^12/L)

7.24

6.74

 

Reticulocytes (x 10^9/L)

70.8

53.3

 

Total white blood cells (x 10^9/L)

11.62

12.34

Coagulation

Activated partial thromboplastin time (s)

12.78

13.59

 

Fibrinogen (mg/dL)

128.3

172.0

 

Prothrombin time (s)

6.08

6.16

Clinical

Adrenocorticotrophic hormone (pg/mL)

32.89

34.68

chemistry

Alanine aminotransferase (U/L)

41.9

39.3

 

Albumin (g/L)

34.75

33.13

 

Albumin/globulin ratio

1.96

1.65

 

Alkaline phosphatase (U/L)

70.50

72.00

 

Amylase (U/L)

900

800

 

Aspartate aminotransferase (U/L)

37.63

35.75

 

Calcium (mmol/L)

2.77

2.76

 

Chloride (mmol/L)

113.50

115.13

 

Cholesterol (mmol/L)

5.96

5.68

 

Creatine kinase (U/L)

306.5

223.4

 

Creatinine (μmol/L)

54.25

50.50

 

C-reactive protein (μg/mL)

3.84

10.16

 

Gamma glutamyl transpeptidase (U/L)

3.50

3.13

 

Globulin (g/L)

18.13

20.38

 

Glucose (mmol/L)

6.24

6.24

 

Inorganic phosphate (mmol/L)

2.14

2.14

 

Lactate dehydrogenase (U/L)

32.50

23.88

 

Magnesium (mmol/L)

0.69

0.71

 

Phospholipid (mmol/L)

6.03

5.83

 

Potassium (mmol/L)

4.75

4.75

 

Sodium (mmol/L)

148.6

147.8

 

Total bile acids (μmol/L)

5.98

4.51

 

Total bilirubin (μmol/L)

1.78

2.10

 

Total protein (g/L)

52.88

53.38

 

Triglycerides (mmol/L)

0.44

0.34

 

Urea (mmol/L)

5.20

4.08

Urinalysis

Bilirubin (mg/dL), ketones (mg/dL), glucose (mg/dL), turbidity

0

0

 

Blood pigments (mg/dL)

0.029

0.004

 

Leukocytes (cells/μL)

150

106

 

pH

6.44

6.44

 

Protein (mg/dL)

8.75

5.00

 

Specific gravity

1.031

1.025

 

Urobilinogen (mg/dL)

0.40

0.20

 

Volume (mL)

133

153

 

Urine color

Light yellow - yellow

 

Microscopic examination (crystals, casts, red blood cells, white blood cells, epithelial cells, bacteria, other abnormalities)

Similar frequency distribution