- Oral presentation
- Open Access
To be or not to be co-infected
Parasites & Vectors volume 7, Article number: O15 (2014)
Ticks can transmit a large spectrum of pathogens including bacteria, viruses and parasites with a significant number of these pathogens being agents of emerging infectious diseases. In Europe, the most prevalent tick-borne disease is Lyme Borreliosis, caused by the bacteria Borrelia burgdorferi s.l. In most cases, Lyme Borreliosis is well diagnosed. However, beside these typical cases, patients bitten by ticks can be infected by many other pathogens (bacteria: Anaplasma spp., Bartonella spp., Rickettsia spp.; parasites: Babesia spp., Theileria spp.; and arboviruses: TBEV) that are more difficult to diagnose. Moreover, co-infections between several of these pathogens might also occur. Clinical surveys show that patients coinfected by several tick-borne pathogens present more severe symptoms and a longer duration of illness than those infected by a single pathogen. The overall objective of our study was to evaluate tick-borne pathogen coinfection in ticks and the consequence of those coinfections for human health.
Using the high throughput real-time PCR chip, we detected the DNA of the 37 major tick-borne pathogens in a cohort of questing adult of Ixodes ricinus ticks collected in Ardennes (France). We identified that 60% of ticks were infected by at least one pathogen and half of the infected ticks were coinfected. We then evaluated the risk for simultaneous infection of those pathogens to humans by detecting the DNA of the most prevalent tick-borne pathogens in the blood of patients bitten by ticks. Our data illustrated the importance of coinfection, and highlighted the necessity to evaluate coinfection in the context of tick-borne diseases.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Moutailler, S., Michelet, L., Chotte, J. et al. To be or not to be co-infected. Parasites Vectors 7 (Suppl 1), O15 (2014). https://doi.org/10.1186/1756-3305-7-S1-O15
- Infectious Disease
- Severe Symptom
- High Throughput
- Typical Case