Skip to main content
  • Poster presentation
  • Open access
  • Published:

Recurrent subcutaneous human Dirofilariasis due to Dirofilaria repens after surgical removal of the worm and anthelmintic treatment

The genus Dirofilaria includes various species that are natural parasites of dogs, cats, foxes, and wild mammals, transmitted by mosquito vectors. Dirofilaria repens is commonly encountered in the subcutaneous tissue of dogs, foxes, and cats. Due to recent increase of human Dirofilaria repens it is considered an emerging zoonosis. In Romania, there are only few reports regarding the infection with D. repens in dogs and in humans. Patients usually present single migratory submucosal or subcutaneous nodule which may or may not be tender. Surgical excision of lesions and affected areas is the treatment of choice for dirofilariasis. Anthelmintics are not usually recommended.

We describe the case of a 65 years old, retired woman, without history of traveling in the past years, living in the Oradea (north-west part of Romania), in an urban area, who presented a left breast subcutaneous nodule with fever and eosinophilia in August 2012. After surgical excision, histopathology and PCR assay (Isolate Genomic DNA Kit, Bioline, UK using 12S ADNr gene (250 bp) the diagnosis of D. repens infection was established. Patient received Albendazole 400 mg/day for 7 days after surgery. The eosinophil count became normal and no symptoms were noticed till December 2012 when another nodular lesion developed in the left breast, accompanied by eosinophilia. After the surgical removal of the second nodule, another larval worm was identified as D. repens. The patient was treated with 150 μg/kg BW of ivermectin and no other nodules appeared. Eosinophiles level remained normal during one year follow-up. This is the first report of autochthonous D. repens infection in humans in the northern part of the country and, to our knowledge, the first case of recurrent subcutaneous human dirofilariasis. The recurrence in this case is most probably the result of infection with multiple larvae, of which at least two developed into nodules at four month interval, rather than a repeated infection. We recommend the treatment with ivermectin after surgical excision to avoid recurrences in dirofilariasis.

Author information

Authors and Affiliations


Corresponding author

Correspondence to M Lupșe.

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Cite this article

Lupșe, M., Mircean, V., Cavasi, A. et al. Recurrent subcutaneous human Dirofilariasis due to Dirofilaria repens after surgical removal of the worm and anthelmintic treatment. Parasites Vectors 7 (Suppl 1), P3 (2014).

Download citation

  • Published:

  • DOI: