The speed of kill of fluralaner (Bravecto™) against Ixodes ricinus ticks on dogs

Parasites & Vectors

Table 1 Mean tick counts and tick-killing efficacy (%) after oral administration of fluralaner to dogs

Assessment time point^a		4 hours	8 hours	12 hours	24 hours
Week 0	Mean tick counts^b (control/treated) [n]	33.0/3.4	30.6/0.6	28.1/0	15.8/0
Week 0	Efficacy [%]	89.6^#	97.9^#	100^#	100^#
Week 4	Mean tick counts^b (control/treated) [n]	36.5/24.4	40.5/1.3	36.7/0.1	30.6/0
Week 4	Efficacy [%]	33.2*	96.8^#	99.7^#	100^#
Week 8	Mean tick counts^b (control/treated) [n]	38.6/31.8	31.2/5.2	32.0/0.3	29.8/0.1
Week 8	Efficacy [%]	17.5	83.5^#	99.2^#	99.6^#
Week 12	Mean tick counts^b (control/treated) [n]	37.4/34.5	30.0/16.2	34.3/0.6	32.7/0.6
Week 12	Efficacy [%]	7.8	45.8^§	98.3^#	98.1^#

^aAssessment for ticks in hours after treatment or re-infestation.
^bGeometric mean.
*Log-counts of live ticks from the treated group were significantly different (p < 0.03) from log-counts of the respective untreated control group.
^*Log counts of live ticks from the treated group were significantly different (p < 0.004) from log-counts of the respective untreated control group.
^#Log counts of live ticks from the treated group were significantly different (p < 0.0001) from log-counts of the respective untreated control group.

ISSN: 1756-3305