Figure 2

Comparison of the IgG response to cE5 and gSG6 in different age groups. (A) Box plots of OD values among responders to cE5 (1–15 n = 94; 16–30 n = 50; >30 n = 53) and to gSG6 (1–15 n = 84; 16–30 n = 40; >30 n = 38) in the three age groups as indicated. Boxes, whiskers and dots as in Figure 1. IgG levels are expressed as OD₄₉₂. P values determined by the Kruskal-Wallis (cE5 P = 0.001; gSG6 ns) and the Mann–Whitney tests (***, p < 0.001; **, p < 0.01). (B) Seroprevalence of anti-cE5 and anti-gSG6 IgG antibodies in the different age groups (1–15 n = 97; 16–30 n = 52; >30 n = 58). Error bars and P value as in Figure 1 (***, p < 0.001). (C) Scatter plot reporting the IgG antibody response to cE5 (red) and to gSG6 (black) as function of age (n = 207). The best-fit lines (solid) and 95% CI (broken lines) are shown. Note that one data point is outside the axis limits.