Onset of activity of fluralaner (BRAVECTO™) against Ctenocephalides felis on dogs

Parasites & Vectors

Table 2 Speed of kill studies: mean flea counts, flea count range and percentage efficacy over 12 weeks after a single oral administration of fluralaner to dogs

Assessment time points^a		4 hours		8 hours		12 hours		24 hours
Study Group		Fluralaner	Control	Fluralaner	Control	Fluralaner	Control	Fluralaner	Control
Week 0	Mean ^b flea counts (n)	4.14	21.21	0.30	49.93	0.0	73.59	0.0	13.85
	Count range (n)	0-21	1-71	0-4	6-80	0	58-79	0	0-75
	Efficacy (%)	80.5%^c		99.4%^c		100%^c		100%^c
Week 4	Mean ^b flea counts (n)	2.38	74.78	0.0	77.79	0.0	73.53	0.0	69.35
	Count range (n)	0-13	69-80	0	73-80	0	66-80	0	61-75
	Efficacy (%)	96.8%^c		100%^c		100%^c		100%^c
Week 8	Mean ^b flea counts (n)	5.71	66.61	0.0	75.01	0.12	69.56	0.0	71.48
	Count range (n)	0-43	60-77	0	62-80	0-1	59-80	0	65-79
	Efficacy (%)	91.4%^c		100%^c		99.8%^c		100%^c
Week 12	Mean ^b flea counts (n)	45.91	69.02	1.49	74.24	1.02	76.44	0.0	73.25
	Count range (n)	15-75	64-75	0-14	67-77	0-16	72-80	0	68-78
	Efficacy (%)	33.5%		98.0%^c		98.7%^c		100%^c

^aAssessment for fleas xy hours after treatment or re-infestation following treatment.
^bGeometric mean.
^cLog-counts of live fleas from the treated group were significantly different (p ≤ 0.05) from log-counts of the respective untreated control group.

ISSN: 1756-3305