Skip to main content

Table 2 Speed of kill studies: mean flea counts, flea count range and percentage efficacy over 12 weeks after a single oral administration of fluralaner to dogs

From: Onset of activity of fluralaner (BRAVECTO™) against Ctenocephalides felis on dogs

Assessment time pointsa 4 hours 8 hours 12 hours 24 hours
Study Group Fluralaner Control Fluralaner Control Fluralaner Control Fluralaner Control
Week 0 Mean b flea counts (n) 4.14 21.21 0.30 49.93 0.0 73.59 0.0 13.85
Count range (n) 0-21 1-71 0-4 6-80 0 58-79 0 0-75
Efficacy (%) 80.5%c 99.4%c 100%c 100%c
Week 4 Mean b flea counts (n) 2.38 74.78 0.0 77.79 0.0 73.53 0.0 69.35
Count range (n) 0-13 69-80 0 73-80 0 66-80 0 61-75
Efficacy (%) 96.8%c 100%c 100%c 100%c
Week 8 Mean b flea counts (n) 5.71 66.61 0.0 75.01 0.12 69.56 0.0 71.48
Count range (n) 0-43 60-77 0 62-80 0-1 59-80 0 65-79
Efficacy (%) 91.4%c 100%c 99.8%c 100%c
Week 12 Mean b flea counts (n) 45.91 69.02 1.49 74.24 1.02 76.44 0.0 73.25
Count range (n) 15-75 64-75 0-14 67-77 0-16 72-80 0 68-78
Efficacy (%) 33.5% 98.0%c 98.7%c 100%c
  1. aAssessment for fleas xy hours after treatment or re-infestation following treatment.
  2. bGeometric mean.
  3. cLog-counts of live fleas from the treated group were significantly different (p ≤ 0.05) from log-counts of the respective untreated control group.