Figure 5

Ciclooxiganese-2 inhibition affects the parasite viability in vivo during L. infantum infection in the presence of SGS. C57BL/6 mice were treated with DMSO (vehicle – Veh) or NS398 2 mg/kg. After 1 h of treatment, mice were injected i.p. with L. infantum and SGS according to methods. Viable parasites counting recovered by total infected peritoneal cells after 1 h L. infantum or L. infantum plus SGS inoculation. Graph shows viable parasites counting recovered by total infected peritoneal cells. The data are the means and SEM from one experiment representative of three independent experiments. n = 5 per group. (*, p < 0.05 and Mann–Whitney test, two-tailed).