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Figure 3 | Parasites & Vectors

Figure 3

From: Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development

Figure 3

Temporal distribution of FIRE motif heat-maps and interaction networks for FM1–11. (A) The motif heat-maps for Fm1–11 are listed according to the earliest point during intraerythrocytic development the associated DNA motif is over-represented. Where a cognate AP2 trans-acting factor is suggested, a heat map illustrating the stage-specific accumulation of mRNA for the AP2 during intraerythrocytic development is shown to the right [32]. Yellow and blue colouring represents temporal patterns of up- and down-regulation of mRNA accumulation during intraerythrocytic development. (B) An interaction network of colocalized Fm DNA motifs. Colocalization of Fm1–11 in the same 5′ flanking region was determined from the motif interaction heat map produced for each group of sequences searched. Repeated discover of these interactions (i.e. in at least two groups) is represented on this network, with the increasing thickness of the connecting arrows representing discovery in two, three or four searches.

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Parasites & Vectors

ISSN: 1756-3305

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