Vaccination with recombinant paramyosin against the bovine lungworm Dictyocaulus viviparus considerably reduces worm burden and larvae shedding

Table 1 Vaccination parameters weight gain, larvae counts and worm burden

Animal ID	Weight gain [kg]	Larvae counts [LPG] ^*	Total worm count	Male worm count	Female worm count
Trial 1
Adjuvant only-control group
110	59	1047	1136	447	689
795	58	569	798	324	474
802	62	53	213	77	136
805	60	302	453	159	294
808	66	304	433	142	291
814	59	153	651	260	391
Arithmetic mean	61.7	404.7	614.0	234.8	379.2
SD_a	2.9	359.8	324.7	136.3	189.4
Geometric mean	60.6	276.7	539.7	200.9	337.9
SD_g ^**	1.0	2.8	1.7	1.8	1.7
rPMY group
806	69	609	925	351	574
812	49	131	4	1	3
813	76	7	64	21	43
822	70	116	126	60	66
Arithmetic mean	66.0	215.8	279.8	108.3	171.5
SD_a	11.7	267.9	433.0	163.7	269.6
Geometric mean	65.1	92.2	77.6	30.2	50.0
SD_g ^**	1.2	5.0	7.0	8.5	6.5
Reduction [%]^***		46.7 (66.7)	54.4 (85.6)	53.9 (85.0)	54.8 (85.2)
Trial 2
GST-control group
361	22	67	940
129	n.a.	12	42
412	30	128	1101
269	53	84	873
553	18	201	1871
Arithmetic mean	30.8	98.4	965.4
SD_a	15.6	70.8	652.0
Geometric mean	28.2	71.2	591.4
SD_g ^**	1.5	2.6	3.8
rPMY group
699	39	87	1019
485	56	73	1192
034	70	25	917
906	76	0	0
887	23	26	209
Arithmetic mean	52.8	42.2	667.4
SD_a	21.9	36.4	528.4
Geometric mean	48.6	20.5	187.0
SD_g ^**	1.1	n.a.	n.a.
Reduction [%]^***		57.1 (71.2)	30.9 (68.4)
Dictol vaccine group
214	48	1	2
688	36	13	152
598	79	1	63
221	48	1	50
825	46	16	56
Arithmetic mean	51.4	6.4^§	64.6
SD_a	16.2	7.5	54.4
Geometric mean	49.7	3.5	37.6
SD_g ^**	1.1	1.5	1.6
Reduction [%]^***		93.5 (95.0)	93.3 (93.6)

SD_a = arithmetic standard deviation, SD_g = geometric standard deviation, n.a. = not available.
^*Values represent the sum of fecal larvae counts from day 84 to 97.
^**SD_g is a multiplicative factor and therefore dimensionless.
^***Percent reduction based on arithmetic mean with values in brackets representing percent reduction based on geometric mean.
^§p ≤ 0.05.

ISSN: 1756-3305