Figure 5From: The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data The effect of the timing of treatment rounds relative to seasonal peaks in transmission by blackfly vectors on programme duration under strategies of annual community-directed treatment with ivermectin (aCDTI) and annual community-directed treatment with moxidectin (aCDTM). The time between treatment and the peak of transmission was varied. The x-axis represents the number of months between treatment at time 0 and the peak of transmission. Scenario 1: transmission only takes place during a five month long rainy season. Scenario 2: high levels of transmission during a five month long rainy season but continuing at a low level during the rest of the year (Table 1 and Additional file 1: Figure S1). The green, blue and red lines correspond to, respectively, a pre-control endemicity level of 40%, 60%, and 80% microfilarial prevalence. The years are those needed to reach the pOTTIS (<1.4% microfilarial prevalence). The lines show the mean microfilarial load per mg of skin after 15 years of treatment in those aged ≥ 20 years. Solid and dashed lines indicate aCDTI and aCDTM respectively. Modelling assumptions are as in the legend of Figure 2.Back to article page