Table 1 Summary of factors whose impact was modelled on the duration and cost of reaching the pOTTIS
Parameters | Values |
|---|---|
Seasonality of transmission (see Supporting information (Additional file 1: Text S.1, and Additional file 1: Figure S1)) | Perennial transmission: annual biting rate (ABR) is constant throughout the year (i.e. no seasonal changes) |
Seasonal transmission scenario 1: transmission occurs during a rainy season typically lasting approximately five months each year; based on foci in Senegal and Mali [7,8] were elimination has been reported | |
Seasonal transmission scenario 2: a longer period of transmission, still peaking in the rainy season but not ceasing completely in the dry season; motivated by the entomological observations in [40] | |
The proportion of the total population receiving ivermectin or moxidectin at each treatment round, referred to as therapeutic coverage | 60% and 80% |
The proportion of the eligible population who never receive treatment, referred to as the proportion of systematic non-compliers | 0.1%, 2% and 5% |
The discount rate applied to the costs [23] | 0%, 3% and 6% |
The per treatment round cost of aCDTM relative to aCDTI | 100% (i.e. the same) and 110% |
The per dose (cumulative) reduction in microfilarial production of female adult worms, referred to as anti-macrofilarial action of ivermectin | 1%, 7% and 30% |
Provisional Operational Thresholds for Transmission Interruption followed by Surveillance (pOTTIS) | 0.9%, 1.4% and 1.9% microfilarial prevalence (i.e. 1.4% ± 0.5%) |