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Table 1 Summary of factors whose impact was modelled on the duration and cost of reaching the pOTTIS

From: The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data

Parameters Values
Seasonality of transmission (see Supporting information (Additional file 1: Text S.1, and Additional file 1: Figure S1)) Perennial transmission: annual biting rate (ABR) is constant throughout the year (i.e. no seasonal changes)
Seasonal transmission scenario 1: transmission occurs during a rainy season typically lasting approximately five months each year; based on foci in Senegal and Mali [7,8] were elimination has been reported
Seasonal transmission scenario 2: a longer period of transmission, still peaking in the rainy season but not ceasing completely in the dry season; motivated by the entomological observations in [40]
The proportion of the total population receiving ivermectin or moxidectin at each treatment round, referred to as therapeutic coverage 60% and 80%
The proportion of the eligible population who never receive treatment, referred to as the proportion of systematic non-compliers 0.1%, 2% and 5%
The discount rate applied to the costs [23] 0%, 3% and 6%
The per treatment round cost of aCDTM relative to aCDTI 100% (i.e. the same) and 110%
The per dose (cumulative) reduction in microfilarial production of female adult worms, referred to as anti-macrofilarial action of ivermectin 1%, 7% and 30%
Provisional Operational Thresholds for Transmission Interruption followed by Surveillance (pOTTIS) 0.9%, 1.4% and 1.9% microfilarial prevalence (i.e. 1.4% ± 0.5%)
  1. aCDTM: annual community-directed treatment with moxidectin; aCDTI: annual community-directed treatment with ivermectin; pOTTIS: provisional operational thresholds for treatment interruption followed by surveillance.