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Table 2 Bioactivity of ALE and ASE against L. donovani promastigotes and amastigotes as well as RAW 264.7 macrophages

From: Apoptosis mediated leishmanicidal activity of Azadirachta indica bioactive fractions is accompanied by Th1 immunostimulatory potential and therapeutic cure in vivo

A. indica fractions/compounds IC 50 (μg ml −1 ) promastigotes IC 50 (μg ml −1 ) amastigotes CC 50 (μg ml −1 ) macrophages SI
ALE 34 ± 0.81 17.66 ± 2.88 461 ± 7.07 26.10
ASE 77.66 ± 3.13 24.66 ± 4.98 >500 -
Pentamidine 1.4 ± 0.249 0.87 ± 0.17 45.0 ± 2.80 51.72
  1. Values represent Mean ± SE, SI = Selectivity Index (calculated as described in Methods), “-” indicates that SI could not be determined.