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Table 2 Changes (least square means values) in APP and oxidative markers and change rates detected during post-vaccination and post-challenge periods

From: Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs

Inflammatory marker Phase of study Group Pre-vaccination or challenge value (standard error) Highest value for positive APP and lowest value for negative APP (standard error) Day of detection (post-vaccination or challenge) Rate of change*
CRP (μg/mL) vaccination 1 6.9 (4.5) 70.6 (11.52) 24 10.23
   2 5 (0) 8.65 (10.66) 13 1.73
  challenge 1 5 (0) 112 (23.31) 22 22.4
   2 5 (0) 173 (23.31) 22 34.6
   3 5 (0) 252 (23.31) 14 50.4
Hp (g/L) vaccination 1 1.68 (1.62) 5.04 (0.73) 24 3
   2 0.28 (0.23) 1.88 (0.69) 24 6.7
  challenge 1 1.56 (0.16) 4.86 (1.21) 22 3.11
   2 1.77 (1.17) 3.78 (1.05) 22 2.13
   3 2.13 (0.29) 8.60 (1.05) 14 4.03
SAA (μg/mL) vaccination 1 5.1 (2.39) 23.94 (2.9) 24 4.69
   2 3.43 (1.92) 5.1 (2.5) 13 1.48
  challenge 1 1.43 (0.97) 61 (9.9) 22 42.65
   2 2.05 (1.29) 36 (8.6) 22 17.56
   3 1.66 (0.43) 156.77 (8.6) 14 94.43
Albumin (g/dL) vaccination 1 3.07 (0.06) 2.33 (0.26) 31 0.75
   2 3 (0.31) 3.01 (0.29) 31 1
  challenge 1 3.64 (0.4) 2.8 (0.15) 22 0.76
   2 3.99 (0.24) 2.8 (0.15) 22 0.7
   3 3.79 (0.19) 1.64 (0.17) 22 0.43
TAC (mmol/L) vaccination 1 0.36 (0.16) 0.07 (0.06) 31 0.19
   2 0.45 (0.017) 0.04 (0.06) 39 0.08
  challenge 1 0.36 (0.06) 0.12 (0.08) 22 0.33
   2 0.46 (0.1) 0.2 (0.06) 14 0.43
   3 0.24 (0.13) 0.08 (0.03) 14 0.33
PON-1 (IU/mL) vaccination 1 2.91 (0.27) 2.1 (0.16) 31 0.72
   2 2.43 (0.29) 2.2 (0.16) 38 0.9
  challenge 1 3.64 (0.6) 2.1 (0.23) 22 0.57
   2 3.9 (0.68) 2.05 (0.23) 22 0.52
   3 3.62 (0.11) 1.3 (0.23) 22 0.35
  1. *Highest or lowest least square means value divided by the mean pre-vaccination or pre-challenge value of the same group.