Skip to main content

Advertisement

Table 1 Selected differentially expressed host cell genes in L. m.-infected BMDM

From: Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210

Selected differentially expressed host cell genes in L. m .-infected BMDM 1 h p.i.
  Gene name (probe set ID) Symbol logFC
Additional autophagy-related genes
  BCL2/adenovirus E1B interacting protein 3 (1422470_at) Bnip3 0.417
Selected differentially expressed host cell genes in L. m .-infected BMDM 24 h p.i.
  Gene name (probe set ID) Symbol logFC
LISA
  ATP-binding cassette, sub-family E (OABP), member 1 (1416014_at) Abce1 0.392
  Acyl-CoA synthetase long-chain family member 4 (1418911_s_at) Acsl4 0.347
  AHA1, activator of heat shock protein ATPase homolog 1 (yeast) (1424147_at) Ahsa1 0.422
  Aldolase A, fructose-bisphosphate (1433604_x_at) Aldoa 0.496
  Adaptor protein complex AP-2, alpha 2 subunit (1432007_s_at) Ap2a2 −0.536
  DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (1447789_x_at) Ddx6 0.598
  Eukaryotic translation initiation factor 2-alpha kinase 2 (1440866_at) Eif2ak2 0.533
  Enolase 2, gamma neuronal (1418829_a_at) Eno2 0.673
  FUN14 domain containing 1 (1453369_a_at) Fundc1 −0.357
  Fusion, derived from t(12;16) malignant liposarcoma (human) (1451285_at) Fus 0.397
  Glyceraldehyde-3-phosphate dehydrogenase (1447999_x_at) Gapdh 0.506
  Helicase, lymphoid specific (1417541_at) Hells 0.505
  Heat shock protein 90, alpha (cytosolic), class A member 1 (1426645_at) Hsp90aa1 0.543
  Potassium channel tetramerisation domain containing 12 (1434881_s_at) Kctd12 −0.419
  Lactate dehydrogenase A (1419737_a_at) Ldha 0.558
  Microtubule-associated protein 1 light chain 3 beta (1415929_at) Map1lc3b −0.445
  Minichromosome maintenance deficient 3 (S. cerevisiae) (1420028_s_at) Mcm3 0.365
  Macrophage migration inhibitory factor (1416335_at) Mif 0.731
  Asparaginyl-tRNA synthetase (1428666_at) Nars −0.384
  N-myc downstream regulated gene 1 (1420760_s_at) Ndrg1 0.545
  Nuclear factor of activated T cells 5 (1438999_a_at) Nfat5 −0.401
  Phosphoglycerate kinase 1 (1417864_at) Pgk1 0.730
  Pyruvate kinase, muscle (1417308_at) Pkm2 0.471
  Protein kinase, AMP-activated, gamma 2 non-catalytic subunit (1423831_at) Prkag2 −0.498
  Sorbitol dehydrogenase (1438183_x_at) Sord −0.385
  Tripartite motif-containing 21 (1418077_at) Trim21 0.400
  Thioredoxin reductase 1 (1421529_a_at) Txnrd1 0.448
  Zinc finger, CCHC domain containing 11 (1437395_at) Zcchc11 −0.477
Additional autophagy-related genes
  BCL2/adenovirus E1B interacting protein 3 (1422470_at) Bnip3 0.765
  Cathepsin E (1418989_at) Ctse −0.852
  DNA-damage regulated autophagy modulator 1 (1424524_at) Dram1 0.445
  Optineurin (1435679_at) Optn 0.355
  Syntaxin 5A (1449679_s_at) Stx5a −0.429
  Vacuolar protein sorting 41 (yeast) (1437901_a_at) Vps41 −0.423
Glycolysis (GO accession: GO:0006096)
  Fructose-bisphosphate aldolase A (1433604_x_at) Aldoa 0.496
  Fructose-bisphosphate aldolase C (1451461_a_at) Aldoc 0.636
  Enolase 2 (1418829_a_at) Eno2 0.673
  Glyceraldehyde-3-phosphate dehydrogenase (1447999_x_at) Gapdh 0.506
  Lactate dehydrogenase A (1419737_a_at) Ldha 0.558
  Phosphoglycerate kinase 1 (1417864_at) Pgk1 0.730
  Phosphoglycerate mutase 1 (1426554_a_at) Pgam1 0.546
  Pyruvate kinase, muscle (1417308_at) Pkm2 0.471
  Protein kinase, AMP-activated, gamma 2 non-catalytic subunit (1423831_at) Prkag2 −0.498
  Triosephosphate isomerase 1 (1415918_a_at) Tpi1 0.670
Immune response (GO accession: GO:0006955)
  BCL2/adenovirus E1B interacting protein 3 (1422470_at) Bnip3 0.765
  Complement component 3 (1423954_at) C3 1.294
  Cell adhesion molecule 1 (1431611_a_at) Cadm1 −0.424
  Chemokine (C-C motif) ligand 12 (1419282_at) Ccl12 0.515
  Chemokine (C-C motif) ligand 2 (1420380_at) Ccl2 0.738
  Chemokine (C-C motif) ligand 24 (1450488_at) Ccl24 −0.485
  Chemokine (C-C motif) ligand 3 (1419561_at) Ccl3 0.643
  Chemokine (C-C motif) ligand 4 (1421578_at) Ccl4 0.710
  Chemokine (C-C motif) ligand 5 (1418126_at) Ccl5 2.250
  Chemokine (C-C motif) ligand 7 (1421228_at) Ccl7 0.523
  CD180 antigen (1421547_at) Cd180 0.382
  CD28 antigen (1437025_at) Cd28 −0.482
  CD300A antigen (1445292_at) Cd300a −0.441
  Complement component factor h (1423153_x_at) Cfh −0.783
  C-type lectin domain family 5, member a (1421366_at) Clec5a 0.804
  Chemokine (C-X3-C) receptor 1 (1450020_at) Cx3cr1 −0.379
  Chemokine (C-X-C motif) ligand 1 (1419209_at) Cxcl1 0.808
  Chemokine (C-X-C motif) ligand 10 (1418930_at) Cxcl10 2.023
  Chemokine (C-X-C motif) ligand 11 (1419697_at) Cxcl11 1.205
  Chemokine (C-X-C motif) ligand 13 (1448859_at) Cxcl13 0.360
  Chemokine (C-X-C motif) ligand 9 (1418652_at) Cxcl9 0.698
  DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (1436562_at) Ddx58 0.520
  Guanylate binding protein 1 (1420549_at) Gbp1 1.349
  Guanylate binding protein 2 (1435906_x_at) Gbp2 1.602
  Guanylate binding protein 3 (1418392_a_at) Gbp3 0.919
  Guanylate binding protein 6 (1438676_at) Gbp6 1.507
  Guanylate binding protein 7 (1434380_at) Gbp7 0.459
  Histocompatibility 28 (1421596_s_at) H28 0.777
  Histocompatibility 2, T region locus 24 (1422160_at) H2-T25 0.847
  Intercellular adhesion molecule 1 (1424067_at) Icam1 0.490
  Interferon induced with helicase C domain 1 (1426276_at) Ifih1 0.664
  Immunoglobulin heavy constant mu (1427351_s_at) Ighm −0.729
  Interleukin 1 receptor antagonist (1425663_at) Il1rn 0.872
  Immunity-related GTPase family M member 1 (1418825_at) Irgm1 0.793
  Kelch-like 6 (Drosophila) (1437886_at) Klhl6 −0.637
  Mucosa associated lymphoid tissue lymphoma translocation gene 1 (1456126_at) Malt1 0.578
  Major facilitator superfamily domain containing 6 (1424463_at) Mfsd6 −0.602
  Macrophage migration inhibitory factor (1416335_at) Mif 0.731
  Myeloid/lymphoid or mixed-lineage leukemia 5 (1434704_at) Mll5 −0.401
  Myxovirus (influenza virus) resistance 1 (1451905_a_at) Mx1 1.226
  Myxovirus (influenza virus) resistance 2 (1419676_at) Mx2 0.494
  NA (1416016_at) NA 0.347
  NA (1417314_at) NA 0.573
  NA (1424775_at) NA 0.540
  NA (1439343_at) NA −0.416
  NA (1447927_at) NA 1.137
  NA (1449009_at) NA 1.397
  Neutrophil cytosolic factor 1 (1425609_at) Ncf1 −0.491
  2′-5′ oligoadenylate synthetase 3 (1425374_at) Oas3 0.545
  2′-5′ oligoadenylate synthetase-like 2 (1453196_a_at) Oasl2 0.762
  ORAI calcium release-activated calcium modulator 1 (1424990_at) Orai1 −0.362
  Proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (1422962_a_at) Psmb8 0.424
  RAB27A, member RAS oncogene family (1429123_at) Rab27a −0.393
  Radical S-adenosyl methionine domain containing 2 (1421009_at) Rsad2 2.096
  Serine (or cysteine) peptidase inhibitor, clade A, member 3G (1424923_at) Serpina3g 0.778
  Tumor necrosis factor (1419607_at) Tnf 0.784
  Tumor necrosis factor (ligand) superfamily, member 10 (1459913_at) Tnfsf10 0.495
  Tumor necrosis factor (ligand) superfamily, member 9 (1422924_at) Tnfsf9 0.726
Chemokine signaling pathway (KEGG entry: mmu04062)
  Adrenergic receptor kinase, beta 1 (1451992_at) Adrbk1 −0.420
  Arrestin, beta 2 (1451987_at) Arrb2 −0.443
  Chemokine (C-C motif) ligand 12 (1419282_at) Ccl12 0.515
  Chemokine (C-C motif) ligand 2 (1420380_at) Ccl2 0.738
  Chemokine (C-C motif) ligand 24 (1450488_at) Ccl24 −0.485
  Chemokine (C-C motif) ligand 3 (1419561_at) Ccl3 0.643
  Chemokine (C-C motif) ligand 4 (1421578_at) Ccl4 0.710
  Chemokine (C-C motif) ligand 5 (1418126_at) Ccl5 2.250
  Chemokine (C-C motif) ligand 7 (1421228_at) Ccl7 0.523
  Chemokine (C-C motif) receptor 1 (1419609_at) Ccr1 0.481
  C-src tyrosine kinase (1423518_at) Csk −0.387
  Chemokine (C-X3-C) receptor 1 (1450020_at) Cx3cr1 −0.379
  Chemokine (C-X-C motif) ligand 1 (1419209_at) Cxcl1 0.808
  Chemokine (C-X-C motif) ligand 10 (1418930_at) Cxcl10 2.023
  Chemokine (C-X-C motif) ligand 11 (1419697_at) Cxcl11 1.205
  Chemokine (C-X-C motif) ligand 13 (1448859_at) Cxcl13 0.360
  Chemokine (C-X-C motif) ligand 9 (1418652_at) Cxcl9 0.698
  Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog (1442804_at) Fgr 0.472
  Neutrophil cytosolic factor 1 (1425609_at) Ncf1 −0.491
  Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (1448306_at) Nfkbia 0.500
  Protein kinase, cAMP dependent, catalytic, beta (1420611_at) Prkacb −0.434
  Signal transducer and activator of transcription 1 (1450034_at) Stat1 0.784
  Signal transducer and activator of transcription 2 (1421911_at) Stat2 0.413
  Signal transducer and activator of transcription 3 (1426587_a_at) Stat3 −0.371