Skip to main content

Advertisement

Table 2 The prevalence and intensity of S. haematobium infections in children from six villages in the Niakhar study area in Central Senegal before treatment with PZQ, 5 weeks post treatment and reinfection levels at 2 to 3 months after draining of ponds and backwater

From: Efficacy of praziquantel against urinary schistosomiasis and reinfection in Senegalese school children where there is a single well-defined transmission period

Characteristics S. haematobium infection
Villages Gajak Godel Logdir Puday Ngalagne kop Sass njafaj Total P-value
Baseline (June 2011)
No. of children infected/examined 77/98 32/52 25/31 37/52 48/52 22/44 241/329 <0.001
Prevalence (95 % CI) 78.6 % (67.2-83.8) 61.5 % (47.9-73.5) 80.6 % (63.7-90.8) 71.1 % (57.7-81.6) 92.3 % (81.8-96.9) 50 % (35.8-64.2) 73.2 % (68.2-77.2)
Numbers of infected children treated with PZQ 75 32 25 36 47 22 237  
GM egg count/10 ml of urine (95 % CI) 169.8 (119.2-241.8) 189.3 (105.6-339.4) 128.3 (73.8-222.8) 966.6 (581.2-1607.5) 1573.9 (1208.2-2050.4) 276.8 (132.2-580.1) 356.1 (286.1-443.3) <0.001
Treatment (August 2011)
Follow-up efficacy of PZQ 5 weeks post treatment (in September 2011)
No. of children infected/examined 7/96 1/52 0/31 1/51 5/51 1/44 15/325  
Prevalence (95 % CI) 7.3 % (3.6-14.3) 2 % (0.3-10.3) 0 % (0–11) 1.9 % (0.3-10.1) 9.8 % (4.2-20.6) 2.3 % (0.4-11.8) 4.6 % (2.7-7.4) 0.219
Numbers of infected treated examined 75 32 25 36 47 22 237  
No of children cured (CR in %) 68 (90.6 %) 31 (96.8 %) 25 (100 %) 35 (97.2 %) 42 (89.4 %) 21 (95.4 %) 222 (93.7 %) 0.7
GM egg count/10 ml of urine (95 % CI) 38.1 (9.1-159) 30.0 . 35.0 64.9 (25.2-167.6) 25.0 43.3 (23.1-81.2) 0.144
ERR in % 77.6 % 84.1 % 100 % 96.4 % 95.9 % 90.9 % 87.8 % 0.92
Reinfection after treatment (September to November 2011)
Follow-up reinfection 2 to 3 months after transmission period in February and March 2012
No. of children infected/examined 15/96 2/52 2/31 14/51 11/51 1/44 45/325  
Prevalence (95 % CI) 15.6 % (9.7-24.2) 3.8 % (1.1-12.9) 6.4 % (1.8-20.2) 26.9 % (16.7-40.2) 21.7.% (12.5-34.6) 2.3 % (0.4-11.8) 13.8 % (10.5-18) 0.002
GM egg count/10 ml of urine (95 % CI) 99.9 (45.1-221.3) 215.6 (0–1.1e + 13) 462.5 (0–5.7e + 11) 30.7 (10–94.5) 12.0 (4.4-33.1) 506.0 48.1 (26.6-86.8) 0.01
No. of children re-infected/surveyed 8/89 1/51 2/31 13/50 6/46 0/43 30/310  
Reinfection rate (95 % CI) 8.9 % (4.6-16.7) 1.9 % (0.3-10.3) 6.4 % (1.7-20.7) 26 % (15.8-39.5) 12.8 % (5.9-25.2) 0 % (0.0-10) 9.7 % (6.9-13.5) <0.001