In-depth characterization of trypsin-like serine peptidases in the midgut of the sugar fed Culex quinquefasciatus

Table 2 General characteristics of Culex quinquefasciatus trypsin-like serine peptidases identified by mass spectrometry ∆

Uniprot accession number	Protein name	Active sitetriad position	Cysteine pair residues	Residues confering substrate specificity	Protein size (aa)		Activation site	Conserved regions
Uniprot accession number	Protein name	Active sitetriad position	Cysteine pair residues	Residues confering substrate specificity	Precursor	Mature	Activation site	LTAAHC	DIAL	GDSGGP
B0WIS4	Trypsin 1	His88, Asp133, Ser229	73-89, 198-214, 225-249	Asp223, Gly246,Gly256	274	226	YR^IVGG	LTAAHC	DYSL	GDSGGP
B0WE94	Trypsin 2	His75, Asp120, Ser216	60-76, 183-200, 212-236	Asp210, Gly234,Gly244	261	226	GK^IVGG	LTAAHC	DFCL	GDSGGP
B0XCW2	Trypsin 4	His70, Asp116, Ser213	151-219, 181-198, 209-233	Asp207, Gly230,Gly240	258	233	FH^IVNG	LTAAHL	DFAL	GDSGGP
B0X667	Trypsin 5	His73, Asp127, Ser221	58-74, 160-227, 192-208, 217-241	Asp215, Gly238,Gly248	293	268	PK^IIGG	LTAAHC	DIAL	GDSGGP
B0XES8	Trypsin 7	His67, Asp112, Ser207	52-68, 146-213, 176-192, 203-227	Asp201, Gly224,Gly234	252	229	SR^IVNG	LTAGHC	DYAL	GDSGGP
B0X870	SP24D	His63, Asp109, Ser195	48-64, 172-181, 191-216	?	240	217	RR^IFGG	LTAAHC	DIAL	GDSGGP
B0W9S9	Serine protease 1/2	His92, Asp135, Ser233	77-93, 202-217, 229-259	?	283	235	SR^IVNG	LTAAHC	DIGL	GDSGGP
B0WW44	Cationic trypsin	His69, Asp114, Ser202	54-70	?	244	216	GR^VVGG	LTAGHC	DIAV	YDGGSP

ISSN: 1756-3305