Research advances in microneme protein 3 of Toxoplasma gondii

Parasites & Vectors

Table 1 Properties of Toxoplasma microneme proteins

MICs	MW(kDa)^a	Domains/homologies	Major putative functions	References
MIC1	49	2 TSRs	Transport/folding of MIC4 and MIC6	[14, 15]
			Binding to host cells
MIC2	83	1 Integrin, 5 TSRs, and 1 TM	Transport M2AP and adhesion	[16, 17]
MIC3	38(90 dimer)	1 CBL and 5 EGF	Adhesion	[14, 18]
MIC4	63	6 Apples	Adhesion	[19, 20]
MIC5	20	Parvulin-like PPIase motif	Suppressing TgSUB1 activity	[21]
MIC6	37	3 EGF-like	Escorter	[20]
MIC7	36	5 EGF-like and 1 TM	unkown	[13]
MIC8	75	1 CBL, 10 EGF-like, and 1 TM	Escorter	[13]
MIC9	32	3 EGF and 1 TM	unkown	[13]
MIC10	23		unkown	[22]
MIC11	22		unkown	[23]
MIC12	234	31 EGF, 4 TSRs, and 1 TM	unkown	[24]
AMA1	60	Cysteine rich	Inhibiting secretion of the rhoptries	[25]
M2AP	35	Beta and coil	Transport/folding of MIC2	[26, 27]
SUB1	85	Subtilase and GPI	Proteolysis	[28]
ROM1	28	Rhomboid	Proteolysis	[29, 30]
SPATR	47.5^b	1 thrombomodulin EGF, 2 TSRs	Trafficking of the protein	[31]
PLP1	124		Cytolysis and parasite egress	[32, 33]
TLN4	256		unkown	[34]

^aBased on the complete open reading frame including signal sequence or GPI anchor signal; ^bPredicted molecular weight (MW) after removal of the signal peptide
Abbreviation: TM transmembrane

ISSN: 1756-3305