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Table 1 Properties of Toxoplasma microneme proteins

From: Research advances in microneme protein 3 of Toxoplasma gondii

MICs MW(kDa)a Domains/homologies Major putative functions References
MIC1 49 2 TSRs Transport/folding of MIC4 and MIC6 [14, 15]
    Binding to host cells  
MIC2 83 1 Integrin, 5 TSRs, and 1 TM Transport M2AP and adhesion [16, 17]
MIC3 38(90 dimer) 1 CBL and 5 EGF Adhesion [14, 18]
MIC4 63 6 Apples Adhesion [19, 20]
MIC5 20 Parvulin-like PPIase motif Suppressing TgSUB1 activity [21]
MIC6 37 3 EGF-like Escorter [20]
MIC7 36 5 EGF-like and 1 TM unkown [13]
MIC8 75 1 CBL, 10 EGF-like, and 1 TM Escorter [13]
MIC9 32 3 EGF and 1 TM unkown [13]
MIC10 23   unkown [22]
MIC11 22   unkown [23]
MIC12 234 31 EGF, 4 TSRs, and 1 TM unkown [24]
AMA1 60 Cysteine rich Inhibiting secretion of the rhoptries [25]
M2AP 35 Beta and coil Transport/folding of MIC2 [26, 27]
SUB1 85 Subtilase and GPI Proteolysis [28]
ROM1 28 Rhomboid Proteolysis [29, 30]
SPATR 47.5b 1 thrombomodulin EGF, 2 TSRs Trafficking of the protein [31]
PLP1 124   Cytolysis and parasite egress [32, 33]
TLN4 256   unkown [34]
  1. aBased on the complete open reading frame including signal sequence or GPI anchor signal; bPredicted molecular weight (MW) after removal of the signal peptide
  2. Abbreviation: TM transmembrane