Fig. 4

Effect of heparin on ANISERP inhibition of human thrombin proteolytic activity. Residual activity of thrombin after incubation with recombinant ANISERP (circles) or AT (squares) with increasing concentrations of heparin (0.1-100 μg/ ml). ANISERP was used at a fixed concentration of 2.17 nM (IC₅₀: 152 nM)