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Table 3 Effect of the studied phytoecdysteroids on the intensity of RH T. gondii proliferation

From: Phytoecdysteroids as modulators of the Toxoplasma gondii growth rate in human and mouse cells

Cmpd. C [μg/mL] Proliferation of parasites [%] in mouse splenocytes
BALB/c C57BL/6
Toxo-positive (N = 10) Toxo-negative (N = 14) Toxo-negative (N = 10)
α-ecdysone 2 89.29 ± 5.90 ↓ 67.77 ± 5.05* 89.69 ± 2.54 ↓
10 91.17 ± 2.89 ↓ 10 % 75.69 ± 2.34* ↓ 39 % 99.75 ± 2.57 ↓ 13 %
20 99.29 ± 4.14 ↓ 106.63 ± 2.67* 102.58 ± 1.85 ↓
20-hydroxy ecdysone 2 88.65 ± 2.55 80.81 ± 3.35* 99.30 ± 2.55
20 88.82 ± 3.11 109.28 ± 2.11* 103.73 ± 3.94
100 90.02 ± 0.52 92.05 ± 2.34 97.76 ± 1.85
sulfadiazine 2 92.91 ± 5.11 78.34 ± 5.14* 85.79 ± 1.55*
20 94.18 ± 2.35 70.87 ± 3.11* 74.65 ± 2.48*
100 81.48 ± 1.52 65.32 ± 3.09* 62.31 ± 2.88*
ConA 2.5 192.60 ± 9.65* 151.48 ± 8.97* 191.62 ± 9.97*
  1. Parasite proliferation was tested on splenocytes obtained from BALB/c mice previously infected with DX T. gondii (Toxo-positive), BALB/c and C57BL/6 uninfected (Toxo-negative) mice, using [3H] uracil incorporation. The statistically significant differences (p < 0.05) were labeled with an asterisk (*); ↓ indicates an increasing pool of protozoans with the increasing concentration of phytoecdysteroids in the splenocyte cultures